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dc.contributor.author Sanchez, Leandro Arturo
dc.contributor.author Gonzalez Sierra, Manuel
dc.contributor.author Siñeriz, Faustino
dc.contributor.author Delgado, Osvaldo Daniel
dc.date.available 2015-08-24T14:58:07Z
dc.date.issued 2013-04
dc.identifier.citation Sanchez, Leandro Arturo; Gonzalez Sierra, Manuel; Siñeriz, Faustino; Delgado, Osvaldo Daniel; Andrimid production at low temperature by a psychrotolerant Serratia proteamaculans strain; Springer; World Journal of Microbiology & Biotechnology; 29; 10; 4-2013; 1-9
dc.identifier.issn 0959-3993
dc.identifier.uri http://hdl.handle.net/11336/1790
dc.description.abstract Andrimid, a known non-ribosomal pseudo- peptide antibiotic, was isolated from a psychrotolerant Serratia proteamaculans strain. The antibiotic peptide was produced at low temperature (8 °C) in a 7.5 l BIOFLO 101 bioreactor under batch culture mode. Andrimid activity from S. proteamaculans culture was only detected at 25 °C and below and potent antibacterial activity was revealed against both, pathogenic and non-pathogenic bacteria. Minimal inhibitory concentration values determined by microdilution experiments varied in the range between 0.01 and 0.78 lg/ml. Antimicrobial purification and structure elucidation were carried out by LC-MS/MS and 1H/13C NMR approaches. The effects on the ultrastructure of sensitive Escherichia coli 35,218 cells were observed by transmission electron microscopy at different inhibition stages. This work demonstrated the significance of biop- rospection from cold environments through the screening of microorganisms with ability to produce cold-active biomolecules of biotechnological interest. S. proteamacu- lans 136 was revealed as a novel microbial source for andrimid production at low temperatures, showing bio- technological potential to be applied in cryopreservation, food or cosmetic industries against pathogenic bacteria.
dc.format application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation © Springer Science+Business Media Dordrecht 2013
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Andrimid
dc.subject Psychrotolerant
dc.subject Serratia proteamaculans
dc.subject Antimicrobial
dc.subject Pseudo-peptide
dc.subject.classification Biología Celular, Microbiología
dc.subject.classification Ciencias Biológicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Andrimid production at low temperature by a psychrotolerant Serratia proteamaculans strain
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-03-30 10:35:44.97925-03
dc.journal.volume 29
dc.journal.number 10
dc.journal.pagination 1-9
dc.journal.pais Alemania
dc.journal.ciudad Berlin
dc.conicet.avisoEditorial Electronic supplementary material The online version of this article (doi:10.1007/s11274-013-1338-9) contains supplementary material, which is available to authorized users.
dc.description.fil Fil: Sanchez, Leandro Arturo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET- Tucumán. Planta Piloto de Procesos Industriales Microbiológicos (i); Argentina;
dc.description.fil Fil: Gonzalez Sierra, Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Rosario. Instituto de Química Rosario; Argentina;
dc.description.fil Fil: Siñeriz, Faustino. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET- Tucumán. Planta Piloto de Procesos Industriales Microbiológicos (i); Argentina;
dc.description.fil Fil: Delgado, Osvaldo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET- Tucumán. Planta Piloto de Procesos Industriales Microbiológicos (i); Argentina;
dc.journal.title World Journal of Microbiology & Biotechnology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11274-013-1338-9
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007/s11274-013-1338-9


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)