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Artículo

Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK

Ferrari, María EdithIcon ; Bernis, Maria EugeniaIcon ; McLeod, Faye; Podpolny, Marina; Coullery, Romina PaolaIcon ; Casadei, Inelia Mailín IaraIcon ; Salinas, Patricia; Rosso, Silvana BeatrizIcon
Fecha de publicación: 06/2018
Editorial: Company of Biologists
Revista: Journal of Cell Science
ISSN: 0021-9533
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología del Desarrollo

Resumen

The formation of complex dendritic arbors is crucial for the assembly of functional networks as abnormal dendrite formation underlies several neurodevelopmental and psychiatric disorders. Many extracellular factors have been postulated as regulators of dendritic growth. Wnt proteins play a critical role in neuronal development and circuit formation. We previously demonstrated that Wnt7b acts through the scaffold protein dishevelled 1 (Dvl1) to modulate dendrite arborisation by activating a non-canonical Wnt signalling pathway. Here,we identify the seven-transmembrane frizzled-7 (Fz7, also known as FZD7) as the receptor for Wnt7b-mediated dendrite growth and complexity. Importantly, Fz7 is developmentally regulated in the intact hippocampus, and is localised along neurites and at dendritic growth cones, suggesting a role in dendrite formation andmaturation. Fz7 lossof- function studies demonstrated that Wnt7b requires Fz7 to promote dendritic arborisation. Moreover, in vivo Fz7 loss of function results in dendritic defects in the intact mouse hippocampus. Furthermore, our findings reveal that Wnt7b and Fz7 induce the phosphorylation of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) and JNK proteins, which are required for dendritic development. Here, we demonstrate that Wnt7b-Fz7 signals through two non-canonical Wnt pathways to modulate dendritic growth and complexity.
Palabras clave: CAMKII , DENDRITE DEVELOPMENT , FZ RECEPTOR , JNK , NEURON , WNT SIGNALLING
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/178755
URL: https://jcs.biologists.org
DOI: http://dx.doi.org/10.1242/jcs.216101
Colecciones
Articulos(CCT - ROSARIO)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - ROSARIO
Articulos(CIQUIBIC)
Articulos de CENTRO DE INVEST.EN QCA.BIOL.DE CORDOBA (P)
Citación
Ferrari, María Edith; Bernis, Maria Eugenia; McLeod, Faye; Podpolny, Marina; Coullery, Romina Paola; et al.; Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK; Company of Biologists; Journal of Cell Science; 131; 13; 6-2018; 1-41
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