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dc.contributor.author
Maiti, Amit K.
dc.contributor.author
Kim Howard, Xana
dc.contributor.author
Viswanathan, Parvathi
dc.contributor.author
Guillen, Laura Cristina
dc.contributor.author
Qian, Xiaoxia
dc.contributor.author
Rojas Villarraga, Adriana
dc.contributor.author
Sun, Celi
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Cañas, Carlos
dc.contributor.author
Tobón, Gabriel J.
dc.contributor.author
Matsuda, Koichi
dc.contributor.author
Shen, Nan
dc.contributor.author
Cherñavsky, Alejandra Claudia
dc.contributor.author
Anaya, Juan Manuel
dc.contributor.author
Nath, Swapan K.
dc.date.available
2022-11-24T10:32:16Z
dc.date.issued
2010-03
dc.identifier.citation
Maiti, Amit K.; Kim Howard, Xana; Viswanathan, Parvathi; Guillen, Laura Cristina; Qian, Xiaoxia; et al.; Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases; Oxford University Press; Rheumatology (oxford, England); 49; 7; 3-2010; 1239-1244
dc.identifier.issn
1462-0324
dc.identifier.uri
http://hdl.handle.net/11336/178745
dc.description.abstract
Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using χ2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ASIA
dc.subject
AUTOIMMUNITY
dc.subject
CD226
dc.subject
LATIN-AMERICA
dc.subject.classification
Genética Humana
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-07-04T19:42:06Z
dc.journal.volume
49
dc.journal.number
7
dc.journal.pagination
1239-1244
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Maiti, Amit K.. Oklahoma Medical Research Foundation; Estados Unidos
dc.description.fil
Fil: Kim Howard, Xana. Oklahoma Medical Research Foundation; Estados Unidos
dc.description.fil
Fil: Viswanathan, Parvathi. Oklahoma Medical Research Foundation; Estados Unidos
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Fil: Guillen, Laura Cristina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Qian, Xiaoxia. New York University Shanghai; China
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Fil: Rojas Villarraga, Adriana. Universidad del Rosario; Corporación Para Investigaciones Biológicas; Bogotá; Colombia
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Fil: Sun, Celi. Oklahoma Medical Research Foundation; Estados Unidos
dc.description.fil
Fil: Cañas, Carlos. Fundación Valle del Lili; Colombia
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Fil: Tobón, Gabriel J.. Fundación Valle del Lili; Colombia
dc.description.fil
Fil: Matsuda, Koichi. University of Tokyo; Japón
dc.description.fil
Fil: Shen, Nan. Shanghai Jiao Tong University School Of Medicine; China
dc.description.fil
Fil: Cherñavsky, Alejandra Claudia. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Anaya, Juan Manuel. Universidad del Rosario; Colombia
dc.description.fil
Fil: Nath, Swapan K.. Oklahoma Medical Research Foundation; Estados Unidos
dc.journal.title
Rheumatology (oxford, England)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1093/rheumatology/kep470
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