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dc.contributor.author
Garces, Mariana Soledad
dc.contributor.author
Caceres, Lourdes Catalina
dc.contributor.author
Chiappetta, Diego Andrés
dc.contributor.author
Magnani, Natalia Daniela
dc.contributor.author
Evelson, Pablo Andrés
dc.date.available
2022-11-24T10:10:27Z
dc.date.issued
2021-08
dc.identifier.citation
Garces, Mariana Soledad; Caceres, Lourdes Catalina; Chiappetta, Diego Andrés; Magnani, Natalia Daniela; Evelson, Pablo Andrés; Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems; Royal Society of Chemistry; New Journal of Chemistry; 45; 32; 8-2021; 14328-14344
dc.identifier.issn
1144-0546
dc.identifier.uri
http://hdl.handle.net/11336/178733
dc.description.abstract
Nanotechnology is an emerging science involving the manipulation of matter at the nanometer scale. Nanoparticles (NP) are engineered structures with at least one dimension of 100 nm or less. These materials are progressively being used for commercial purposes and being incorporated into everyday manufactured articles at an increasing rate. These products include consumer items such as pharmaceuticals, cosmetics, food, food packaging, and household products, among others. The same unique physical and chemical properties that make NP so attractive may be associated with their potentially hazardous effects on cells and tissues. Despite the large benefit ensured from the application of nanotechnology, many issues related to NP behavior and adverse effects are not fully understood or should be examined anew. The traditional hypothesis that NP exhibit different or additional hazards due to their ?nano? size has been challenged in recent years, and NP categorization according to their properties and toxicity mechanism has been proposed instead. Possible undesirable results of these capabilities are harmful interactions with biological systems and the environment, with the potential to generate toxicity. Both in vivo and in vitro studies have shown that NP are closely associated with toxicity by increasing intracellular reactive oxygen species (ROS) levels, and/or the levels of pro-inflammatory mediators. This review summarizes available data on NP toxicity in biological systems, with particular focus on oxidative stress and inflammation as the main mechanisms that lead to adverse health effects following NP exposure.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NANOTOXICOLOGY
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REACTIVE OXYGEN SPECIES
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OXIDATIVE STRESS
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INFLAMMATION
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-10-04T17:53:39Z
dc.journal.volume
45
dc.journal.number
32
dc.journal.pagination
14328-14344
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Garces, Mariana Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Caceres, Lourdes Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Chiappetta, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina
dc.description.fil
Fil: Magnani, Natalia Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Evelson, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.journal.title
New Journal of Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/en/Content/ArticleLanding/2021/NJ/D1NJ01415C
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/D1NJ01415C
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