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dc.contributor.author
León, Antonella
dc.contributor.author
Aparicio, Gabriela Inés
dc.contributor.author
Scorticati, Camila
dc.date.available
2022-11-22T11:03:49Z
dc.date.issued
2021-05
dc.identifier.citation
León, Antonella; Aparicio, Gabriela Inés; Scorticati, Camila; Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction; Frontiers Media; Frontiers in Synaptic Neuroscience; 13; 661681; 5-2021; 1-9
dc.identifier.uri
http://hdl.handle.net/11336/178452
dc.description.abstract
The cellular and molecular mechanisms underlying neuropsychiatric and neurodevelopmental disorders show that most of them can be categorized as synaptopathies—or damage of synaptic function and plasticity. Synaptic formation and maintenance are orchestrated by protein complexes that are in turn regulated in space and time during neuronal development allowing synaptic plasticity. However, the exact mechanisms by which these processes are managed remain unknown. Large-scale genomic and proteomic projects led to the discovery of new molecules and their associated variants as disease risk factors. Neuronal glycoprotein M6a, encoded by the GPM6A gene is emerging as one of these molecules. M6a has been involved in neuron development and synapse formation and plasticity, and was also recently proposed as a gene-target in various neuropsychiatric disorders where it could also be used as a biomarker. In this review, we provide an overview of the structure and molecular mechanisms by which glycoprotein M6a participates in synapse formation and maintenance. We also review evidence collected from patients carrying mutations in the GPM6A gene; animal models, and in vitro studies that together emphasize the relevance of M6a, particularly in synapses and in neurological conditions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers Media
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
GPM6A
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NEURONAL PLASTICITY
dc.subject
SYNAPTOPATHY
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SYNAPTIC INTERACTOME
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PLP FAMILY
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Otras Ciencias Naturales y Exactas
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Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Neuronal Glycoprotein M6a: An Emerging Molecule in Chemical Synapse Formation and Dysfunction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-20T11:07:54Z
dc.identifier.eissn
1663-3563
dc.journal.volume
13
dc.journal.number
661681
dc.journal.pagination
1-9
dc.journal.pais
Suiza
dc.description.fil
Fil: León, Antonella. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Aparicio, Gabriela Inés. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
dc.description.fil
Fil: Scorticati, Camila. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; Argentina
dc.journal.title
Frontiers in Synaptic Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnsyn.2021.661681/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fnsyn.2021.661681
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