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dc.contributor.author
Cuggino, Julio César
dc.contributor.author
Molina, Maria
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Wedepohl, Stefanie
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Alvarez Igarzabal, Cecilia Ines
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Calderon, Marcelo
dc.contributor.author
Gugliotta, Luis
dc.date.available
2017-06-08T15:27:56Z
dc.date.issued
2016-05
dc.identifier.citation
Cuggino, Julio César; Molina, Maria; Wedepohl, Stefanie; Alvarez Igarzabal, Cecilia Ines; Calderon, Marcelo; et al.; Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems; Elsevier; European Polymer Journal; 78; 5-2016; 14-24
dc.identifier.issn
0014-3057
dc.identifier.uri
http://hdl.handle.net/11336/17766
dc.description.abstract
Various specially designed poly(N-isopropylacrylamide-co-acrylic acid) (NIPA-co-AAc) nanogels (NGs) with different NIPA/AAc molar composition were synthesized by precipitation/dispersion polymerization and evaluated as carriers for drug delivery systems (DDSs) of doxorubicin hydrochloride (DOXO·HCl) for cancer therapies. The NGs presented excellent dispersability in physiological environments (pH 7.4 and 5 at 37 °C), as shown by dynamic light scattering (DLS). Moreover, the NGs exhibited high drug loading capacity and efficiency due to the ionic interaction of the cationic drug with the anionic NGs. NG-DOXO·HCl formulation presented excellent dispersability in water and minimal leakage of the cargo at plasma simulated medium (pH 7.4 and 0.14 M NaCl) at 37 °C and a triggered release at lysosomal simulated medium (pH 5 and 0.14 M NaCl). This release behavior together with their size and the low cytotoxicity determined by the MTT assay converts these NGs in great candidates for their application as carriers in cancer therapies based on the enhanced permeability and retention effect (EPR) with drug pH-triggered release after endocytosis in tumor cells.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
CANCER
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DOXORUBICIN
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DRUG DELIVERY
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IONIC COMPLEXES
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NANOGELS
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NANOMEDICINE
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NIPA-CO-AAC
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PH TRIGGERED
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Físico-Química, Ciencia de los Polímeros, Electroquímica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-06T14:42:53Z
dc.identifier.eissn
1873-1945
dc.journal.volume
78
dc.journal.pagination
14-24
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Cuggino, Julio César. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Molina, Maria. Freie Universität Berlin. Institut für Chemie und Biochemie; Alemania
dc.description.fil
Fil: Wedepohl, Stefanie. Freie Universität Berlin. Institut für Chemie und Biochemie; Alemania
dc.description.fil
Fil: Alvarez Igarzabal, Cecilia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
dc.description.fil
Fil: Calderon, Marcelo. Freie Universität Berlin. Institut für Chemie und Biochemie; Alemania
dc.description.fil
Fil: Gugliotta, Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.journal.title
European Polymer Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014305716300787
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.eurpolymj.2016.02.022
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