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dc.contributor.author
Jaworski, Juan Pablo
dc.contributor.author
Cahn, Pedro
dc.date.available
2022-11-11T16:38:03Z
dc.date.issued
2018-09
dc.identifier.citation
Jaworski, Juan Pablo; Cahn, Pedro; Preventive and therapeutic features of broadly neutralising monoclonal antibodies against HIV-1; Elsevier; The Lancet HIV; 5; 12; 9-2018; 723-731
dc.identifier.issn
2352-3018
dc.identifier.uri
http://hdl.handle.net/11336/177513
dc.description.abstract
The viral plasticity and the vast diversity of HIV-1 circulating strains necessitates the identification of new approaches to control this global pandemic. New generation broadly neutralising monoclonal antibodies (bnMAbs) against the HIV-1 viral envelope protein (Env) can prevent virus acquisition, reduce viraemia, enhance immunity, and induce the killing of infected cells in animal models of HIV-1 infection. Most importantly, passively administered bnMAbs are effective at decreasing viraemia and delaying viral rebound in people chronically infected with HIV-1. Single antibody treatment is associated with the emergence of viral escape mutants, and virus suppression is not maintained in the long term. However, a combination of bnMAbs and bioengineered multivalent antibodies that target different sites on Env might increase the efficacy of immunotherapy, adding a new relevant tool for clinical use. The aim of this Review is to highlight the potential benefits of this novel prophylactic and therapeutic approach to fight HIV-1.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HIV
dc.subject
anticuerpos
dc.subject
profilaxis
dc.subject
terapia
dc.subject.classification
Virología
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.subject.classification
Inmunología
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Preventive and therapeutic features of broadly neutralising monoclonal antibodies against HIV-1
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-11-10T15:27:30Z
dc.journal.volume
5
dc.journal.number
12
dc.journal.pagination
723-731
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Jaworski, Juan Pablo. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cahn, Pedro. Fundación Huésped; Argentina
dc.journal.title
The Lancet HIV
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2352301818301747
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/S2352-3018(18)30174-7
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