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dc.contributor.author Katche, Cynthia Lorena
dc.contributor.author Medina, Jorge Horacio
dc.date.available 2017-06-08T00:04:18Z
dc.date.issued 2015-12
dc.identifier.citation Katche, Cynthia Lorena; Medina, Jorge Horacio; Requirement of an early activation of BDNF/c-fos cascade in the retrosplenial cortex for the persistence of a long-lasting aversive memory; Oxford University Press; Cerebral Cortex; 27; 2; 12-2015; 1060-1067
dc.identifier.issn 1047-3211
dc.identifier.uri http://hdl.handle.net/11336/17746
dc.description.abstract During the past few years, there has been growing interest in the role of the retrosplenial cortex (RSC) in memory processing. However, little is known about the molecular changes that take place in this brain region during memory formation. In the present work, we studied the early post-training participation of RSC in the formation of a long-lasting memory in rats. We found an increase in c-Fos levels in the anterior part of the RSC (aRSC) after inhibitory avoidance (IA) training. Interestingly, this increase was associated with memory durability, since blocking c-Fos expression using specific antisense oligonucleotides (ASO) impaired long-lasting retention 7 days after training without affecting memory expression 2 days after training. In addition, we showed that BDNF is one of the upstream signals for c-Fos expression required for memory persistence, since blocking BDNF synthesis prevents IA training-induced increase in c-Fos levels in aRSC and affects memory persistence. In addition, we found that injection of BDNF into aRSC around training was sufficient to establish a persistent memory and that this effect was prevented by c-fos ASO infusion into the same structure. These findings reveal an early post-training involvement of aRSC in the processing of a long-lasting aversive memory.
dc.format application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject IEG
dc.subject Inhibitory avoidance
dc.subject Memory persistence
dc.subject Rat
dc.subject.classification Neurociencias
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Requirement of an early activation of BDNF/c-fos cascade in the retrosplenial cortex for the persistence of a long-lasting aversive memory
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-06-07T20:38:36Z
dc.journal.volume 27
dc.journal.number 2
dc.journal.pagination 1060-1067
dc.journal.pais Reino Unido
dc.journal.ciudad Oxford
dc.description.fil Fil: Katche, Cynthia Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.description.fil Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
dc.journal.title Cerebral Cortex
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/cercor/article-lookup/doi/10.1093/cercor/bhv284
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/cercor/bhv284


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  • Articulos(IBCN) [212]
    Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)