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dc.contributor.author
Diaz, Silvina Laura
dc.contributor.author
Narboux Nême, Nicolas
dc.contributor.author
Boutourlinsky, Katia
dc.contributor.author
Doly, Stéphane
dc.contributor.author
Maroteaux, Luc
dc.date.available
2017-06-07T23:59:31Z
dc.date.issued
2016-02
dc.identifier.citation
Diaz, Silvina Laura; Narboux Nême, Nicolas; Boutourlinsky, Katia; Doly, Stéphane; Maroteaux, Luc; Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants; Elsevier Science; European Neuropsychofarmacology; 26; 2; 2-2016; 265-279
dc.identifier.issn
0924-977X
dc.identifier.uri
http://hdl.handle.net/11336/17743
dc.description.abstract
Depressive disorders are among the most prevalent neuropsychiatric dysfunctions worldwide, with high rates of resistance to antidepressant treatment. Genetic factors clearly contribute to the manifestation of depression as well as to the response to antidepressants. Transgenic mouse models appear as seminal tools to disentangle this complex disorder. Here, we analyzed new key aspects of the phenotype of knock-out mice for the gene encoding the serotonin 2B receptor (Htr2B−/−), including basal phenotype, ability to develop a depressive-like phenotype upon chronic isolation, and effect of chronic exposure to fluoxetine on chronically stressed Htr2B−/− mice. We find, here, that Htr2B−/− mice display an antidepressant-like phenotype, which includes reduced latency to feed in the novelty suppressed feeding test, basal increase in hippocampal BDNF levels, no change in TrkB and p75 protein levels, and an increased preference for sucrose consumption compared to wild type (Htr2B+/+) mice. Nevertheless, we show that these mice can develop depressive-like behaviors when socially isolated during four weeks. Selective serotonin reuptake inhibitors (SSRI) have been previously shown to be ineffective in non-stressed Htr2B−/− mice. We evaluated, here, the effects of the SSRI fluoxetine in chronically stressed Htr2B−/− mice and similarly no behavioral or plastic effect was induced by this antidepressant. All together, these results highlight the suitability to study resistance to SSRI antidepressants of this mouse model displaying panoply of conditions among which behavioral, neurotrophic and plastic causative factors can be analyzed.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Serotonin
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5-Ht2b
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Receptor
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Chronic Stress
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Ssri Antidepressants
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Depression
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-06-07T20:38:51Z
dc.journal.volume
26
dc.journal.number
2
dc.journal.pagination
265-279
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Diaz, Silvina Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Inserm; Francia. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Narboux Nême, Nicolas. Inserm; Francia. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Boutourlinsky, Katia. Inserm; Francia. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Doly, Stéphane. Inserm; Francia. Universite Pierre et Marie Curie; Francia
dc.description.fil
Fil: Maroteaux, Luc. Inserm; Francia. Universite Pierre et Marie Curie; Francia
dc.journal.title
European Neuropsychofarmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.euroneuro.2015.12.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0924977X15003958
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