Artículo
Marginal zone B cells emerge as a critical component of pregnancy well-being
Muzzio, Damián Oscar; Ziegler, Katharina B.; Ehrhardt, Jens; Zygmunt, Marek; Jensen, Cristian Federico
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Fecha de publicación:
10/2015
Editorial:
BioScientifica
Revista:
Reproduction
ISSN:
1470-1626
e-ISSN:
1741-7899
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The success of eutherian mammal evolution was certainly supported by the ability of the already existing immune system to adapt to the presence of the semi-allogeneic fetus without losing the capability to defend the mother against infections. This required the acquisition of highly regulated and coordinated immunological mechanisms. Failures in the development of these strategies not only lead to the interruption of pregnancy but also compromise maternal health. Alongside changes on the cytokine profile - expansion of tolerogenic dendritic and regulatory T cells - a profound adaptation of the B cell compartment during pregnancy was recently described. Among others, the suppression of B cell lymphopoiesis and B cell lymphopenia were proposed to be protective mechanisms tending to reduce the occurrence of autoreactive B cells that might recognize fetal structures and put pregnancy on risk. On the other hand, expansion of the pre-activated marginal zone (MZ) B cell phenotype was described as a compensatory strategy launched to overcome B cell lymphopenia thus ensuring a proper defense. In this work, using an animal model of pregnancy disturbances, we demonstrated that the suppression of B cell lymphopoiesis as well as splenic B cell lymphopenia occur independently of pregnancy outcome. However, only animals undergoing normal pregnancies, but not those suffering from pregnancy disturbances, could induce an expansion and activation of the MZ B cells. Hence, our results clearly show that MZ B cells, probably due to the production of natural protective antibodies, participate in the fine balance of immune activation required for pregnancy well-being.
Palabras clave:
B Cells
,
Pregnancy
,
Tolerance
Archivos asociados
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Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Muzzio, Damián Oscar; Ziegler, Katharina B.; Ehrhardt, Jens; Zygmunt, Marek; Jensen, Cristian Federico; Marginal zone B cells emerge as a critical component of pregnancy well-being; BioScientifica; Reproduction; 151; 10-2015; 29-37
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