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dc.contributor.author
Baquedano, María Sonia
dc.contributor.author
Belgorosky, Alicia
dc.date.available
2022-11-10T13:15:03Z
dc.date.issued
2018-07
dc.identifier.citation
Baquedano, María Sonia; Belgorosky, Alicia; Human Adrenal Cortex: Epigenetics and Postnatal Functional Zonation; Karger; Hormone Research in Paediatrics; 89; 5; 7-2018; 331-340
dc.identifier.issn
1663-2818
dc.identifier.uri
http://hdl.handle.net/11336/177250
dc.description.abstract
The human adrenal cortex, involved in adaptive responses to stress, fluid homeostasis, and secondary sexual characteristics, arises from a tightly regulated development of a zone and cell type-specific secretory pattern. However, the molecular mechanisms governing adrenal zonation, particularly postnatal zona reticularis development, which produce adrenal androgens in a lifetime-specific manner, remain poorly understood. Epigenetic events, including DNA and histone modifications as well as regulation by noncoding RNAs, are crucial in establishing or maintaining the expression pattern of specific genes and thus contribute to the stability of a specific differentiation state. Emerging evidence points to epigenetics as another regulatory layer that could contribute to establishing the adrenal zone-specific pattern of enzyme expression. Here, we outline the developmental milestones of the human adrenal cortex, focusing on current advances and understanding of epigenetic regulation of postnatal functional zonation. Numerous questions remain to be addressed emphasizing the need for additional investigations to elucidate the role of epigenetics in the human adrenal gland. Ultimately, improved understanding of the epigenetic factors involved in adrenal development and function could lead to novel therapeutic interventions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Karger
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADRENARCHE
dc.subject
DNA METHYLATION
dc.subject
EPIGENETICS
dc.subject
HISTONE MODIFICATIONS
dc.subject
HUMAN ADRENAL ZONATION
dc.subject
MIRNAS
dc.subject
STEROIDOGENESIS
dc.subject.classification
Bioquímica y Biología Molecular
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Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Human Adrenal Cortex: Epigenetics and Postnatal Functional Zonation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-11-08T13:57:12Z
dc.identifier.eissn
1663-2826
dc.journal.volume
89
dc.journal.number
5
dc.journal.pagination
331-340
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Baquedano, María Sonia. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Belgorosky, Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
dc.journal.title
Hormone Research in Paediatrics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.karger.com/Article/Abstract/487995
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000487995
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