Artículo
Effect of experimental glaucoma on the non-image forming visual system
de Zavalia, Nuria Maria Asuncion
; Plano, Santiago Andrés
; Fernandez, Diego Carlos
; Lanzani, María Florencia; Salido, Ezequiel Martin
; Belforte, Nicolás Adalberto
; Keller Sarmiento, Maria Ines
; Golombek, Diego Andres
; Rosenstein, Ruth Estela
Fecha de publicación:
06/2011
Editorial:
Wiley
Revista:
Journal of Neurochemistry
ISSN:
0022-3042
e-ISSN:
1471-4159
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Glaucoma is a leading cause of blindness worldwide, characterized by retinal ganglion cell degeneration and damage to the optic nerve. We investigated the non-image forming visual system in an experimental model of glaucoma in rats induced by weekly injections of chondroitin sulphate (CS) in the eye anterior chamber. Animals were unilaterally or bilaterally injected with CS or vehicle for 6 or 10 weeks. In the retinas from eyes injected with CS, a similar decrease in melanopsin and Thy-1 levels was observed. CS injections induced a similar decrease in the number of melanopsin-containing cells and superior collicular retinal ganglion cells. Experimental glaucoma induced a significant decrease in the afferent pupil light reflex. White light significantly decreased nocturnal pineal melatonin content in control and glaucomatous animals, whereas blue light decreased this parameter in vehicle- but not in CS-injected animals. A significant decrease in light-induced c-Fos expression in the suprachiasmatic nuclei was observed in glaucomatous animals. General rhythmicity and gross entrainment appear to be conserved, but glaucomatous animals exhibited a delayed phase angle with respect to lights off and a significant increase in the percentage of diurnal activity. These results indicate the glaucoma induced significant alterations in the non-image forming visual system.
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Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
de Zavalia, Nuria Maria Asuncion; Plano, Santiago Andrés; Fernandez, Diego Carlos; Lanzani, María Florencia; Salido, Ezequiel Martin; et al.; Effect of experimental glaucoma on the non-image forming visual system; Wiley; Journal of Neurochemistry; 117; 5; 6-2011; 904-914
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