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dc.contributor.author
Choi, Marcelo Roberto
dc.contributor.author
Cavallero, Carmen Susana
dc.contributor.author
Fernandez, Belisario Enrique
dc.date.available
2015-08-24T13:35:50Z
dc.date.issued
2011-10
dc.identifier.citation
Choi, Marcelo Roberto; Cavallero, Carmen Susana; Fernandez, Belisario Enrique; The renin angiotensin system in the central nervous system; Sociedad Argentina de Fisiología; Physiological Mini Reviews; 5; 5; 10-2011; 18-31
dc.identifier.issn
1669-5402
dc.identifier.uri
http://hdl.handle.net/11336/1766
dc.description.abstract
The first evidences indicating that angiotensin II (ANG II) was a peptide with action on the brain were shown in 1961 when it was found that the intraventricular injection of ANG II induces a centrally mediated pressor response. As a neuropeptide, ANG II belongs to the class of neuromodulators. The brain renin angiotensin system (RAS) exerts paracrine, autocrine and intracrine functions independently of circulating blood-borne ANG II which has a limited access to the brain by the blood-brain barrier (BBB) in the circumventricular organs (CVOs). Brain-generated ANG II controls several physiological processes like stimulation of thirst, water intake and sodium appetite, acting as a neurotransmitter in neurons of brain areas such as the Subfornical organ (SFO) and Organum vasculosum of the lamina terminalis (OVLT). Generated angiotensins (ANGs) at the central nervous system (CNS) also stimulate endocrine secretions like argininevasopressin (AVP), oxytocin (OT), corticotrophin-releasing hormone (CRH) and adenocorticotrophin (ACTH secretion). Brain ANG II modulates the sympathetic autonomic functions and regulates blood pressure by increasing AVP and ACTH secretion and modulating the baroceptor reflex and the sympathetic output. During the last decade it has been established that, apart from its classical actions, ANG II exhibits other effects induced by direct action on its receptors or via local effects of its metabolites . Thereby, central actions of ANGs are not exclusively associated with their traditional roles. Indeed, several studies have shown that central ANGs are also involved in sexual behavior, stress, learning, and memory.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Sociedad Argentina de Fisiología
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Angiotensin
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Central Nervous System
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At1 Receptor
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At 2 Receptor
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Neurología Clínica
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
The renin angiotensin system in the central nervous system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1669-5410
dc.journal.volume
5
dc.journal.number
5
dc.journal.pagination
18-31
dc.journal.pais
Argentina
dc.journal.ciudad
Ciudad Autónoma de Buenos Aires
dc.description.fil
Fil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
dc.description.fil
Fil: Cavallero, Carmen Susana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Cs.biologicas. Cat.de Fisiopatologia; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
dc.description.fil
Fil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;
dc.journal.title
Physiological Mini Reviews
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pmr.safisiol.org.ar/uploadsarchivos/vol_5___5_2011_the_renin....choi_et_al..pdf


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