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dc.contributor.author
Fendrik, Alejandro José
dc.contributor.author
Romanelli, Lilia Mabel
dc.contributor.author
Rotondo, Ernesto Federico
dc.date.available
2022-11-01T11:34:15Z
dc.date.issued
2019-11
dc.identifier.citation
Fendrik, Alejandro José; Romanelli, Lilia Mabel; Rotondo, Ernesto Federico; Stochastic cell renewal process and lengthening of cell cycle; IOP Publishing; Physical Biology; 17; 1; 11-2019; 1-12
dc.identifier.issn
1478-3967
dc.identifier.uri
http://hdl.handle.net/11336/175753
dc.description.abstract
Evolution of the stem cell population responsible for homeostatic cell renewal processes is analyzed. We assume that this regime is the product of a delicate balance between symmetric divisions that, after each cell cycle, originates a new stem cell or its disappearance (through cell differentiation). This dynamics leads to a monoclonal population, that is for an initial homogeneous set of stem cells, fixation of each clone is equiprobable. In this work we show that if there is an altered stem cell with a longer cell cycle than the rest, the fixation of this altered clone is more likely. We also study the consequeces of the appearance of successive alterations with these characteristics and their fixations. This effect is purely due to inherent characteristics of the cell renewal dynamics and as time goes by it leads to a quiescence state for stem cells owing to the recurrent fixation of such altered cells. Therefore it would contribute to the aging process.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
IOP Publishing
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGING
dc.subject
REPLICATIVE SENESCENCE
dc.subject
STEM CELLS
dc.subject.classification
Otras Ciencias Físicas
dc.subject.classification
Ciencias Físicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Stochastic cell renewal process and lengthening of cell cycle
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-10-26T10:48:01Z
dc.journal.volume
17
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Fendrik, Alejandro José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.description.fil
Fil: Romanelli, Lilia Mabel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.description.fil
Fil: Rotondo, Ernesto Federico. Universidad Nacional de General Sarmiento. Instituto de Ciencias; Argentina
dc.journal.title
Physical Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://iopscience.iop.org/article/10.1088/1478-3975/ab576c
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1088/1478-3975/ab576c
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