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dc.contributor.author
Truyens, Carine  
dc.contributor.author
Dumonteil, Eric  
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Alger, Jackeline  
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Cafferata, Maria Luisa  
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Ciganda, Alvaro  
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Gibbons, Luz  
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Herrera, Claudia  
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Sosa-Estani, Sergio Alejandro  
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Buekens, Pierre  
dc.date.available
2022-10-31T10:25:55Z  
dc.date.issued
2021-11  
dc.identifier.citation
Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-8  
dc.identifier.issn
0095-1137  
dc.identifier.uri
http://hdl.handle.net/11336/175516  
dc.description.abstract
Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Society for Microbiology  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CHAGAS DISEASE  
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DIAGNOSTIC PERFORMANCE  
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DIAGNOSTICS  
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ELISA  
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RAPID TEST  
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REACTIVITY  
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SEROLOGY  
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STRAIN DIVERSITY  
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Enfermedades Infecciosas  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-29T13:47:06Z  
dc.journal.volume
59  
dc.journal.number
12  
dc.journal.pagination
1-8  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Truyens, Carine. Université Libre de Bruxelles; Bélgica  
dc.description.fil
Fil: Dumonteil, Eric. University of Tulane; Estados Unidos  
dc.description.fil
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras  
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Fil: Cafferata, Maria Luisa. No especifíca;  
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Fil: Ciganda, Alvaro. No especifíca;  
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Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina  
dc.description.fil
Fil: Herrera, Claudia. University of Tulane; Estados Unidos  
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Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina  
dc.description.fil
Fil: Buekens, Pierre. University of Tulane; Estados Unidos  
dc.journal.title
Journal of Clinical Microbiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/JCM.01062-21