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dc.contributor.author
Truyens, Carine
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dc.contributor.author
Dumonteil, Eric
dc.contributor.author
Alger, Jackeline
dc.contributor.author
Cafferata, Maria Luisa
dc.contributor.author
Ciganda, Alvaro
dc.contributor.author
Gibbons, Luz
dc.contributor.author
Herrera, Claudia
dc.contributor.author
Sosa-Estani, Sergio Alejandro
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dc.contributor.author
Buekens, Pierre
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dc.date.available
2022-10-31T10:25:55Z
dc.date.issued
2021-11
dc.identifier.citation
Truyens, Carine; Dumonteil, Eric; Alger, Jackeline; Cafferata, Maria Luisa; Ciganda, Alvaro; et al.; Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection; American Society for Microbiology; Journal of Clinical Microbiology; 59; 12; 11-2021; 1-8
dc.identifier.issn
0095-1137
dc.identifier.uri
http://hdl.handle.net/11336/175516
dc.description.abstract
Chagas disease is a neglected disease caused by Trypanosoma cruzi parasites. Most diagnosis is based on serological tests, but the lack of a gold standard test complicates the measurement of test performance. To overcome this limitation, we used samples from a cohort of well-characterized T. cruzi-infected women to evaluate the reactivity of two rapid diagnostic tests and one enzyme-linked immunosorbent assay (ELISA). Our cohort was derived from a previous study on congenital transmission of T. cruzi and consisted of 481 blood/plasma samples from Argentina (n = 149), Honduras (n = 228), and Mexico (n = 104), with at least one positive T. cruzi PCR. Reactivity of the three tests ranged from 70.5% for the Wiener ELISA to 81.0% for the T-Detect and 90.4% for the Stat-Pak rapid tests. Test reactivity varied significantly among countries and was highest in Argentina and lowest in Mexico. When considering at least two reactive serological tests to confirm seropositivity, over 12% of T. cruzi infection cases from Argentina were missed by serological tests, over 21% in Honduras, and an alarming 72% in Mexico. Differences in test performance among countries were not due to differences in parasitemia, but differences in antibody levels against ELISA antigens were observed. Geographic differences in T. cruzi parasite strains as well as genetic differences among human populations both may contribute to the discrepancies in serological testing. Improvements in serological diagnostics for T. cruzi infections are critically needed to ensure an optimum identification of cases.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society for Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHAGAS DISEASE
dc.subject
DIAGNOSTIC PERFORMANCE
dc.subject
DIAGNOSTICS
dc.subject
ELISA
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RAPID TEST
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REACTIVITY
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SEROLOGY
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STRAIN DIVERSITY
dc.subject.classification
Enfermedades Infecciosas
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dc.subject.classification
Ciencias de la Salud
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Geographic Variations in Test Reactivity for the Serological Diagnosis of Trypanosoma cruzi Infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-29T13:47:06Z
dc.journal.volume
59
dc.journal.number
12
dc.journal.pagination
1-8
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Truyens, Carine. Université Libre de Bruxelles; Bélgica
dc.description.fil
Fil: Dumonteil, Eric. University of Tulane; Estados Unidos
dc.description.fil
Fil: Alger, Jackeline. Universidad Nacional Autónoma de Honduras; Honduras
dc.description.fil
Fil: Cafferata, Maria Luisa. No especifíca;
dc.description.fil
Fil: Ciganda, Alvaro. No especifíca;
dc.description.fil
Fil: Gibbons, Luz. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Herrera, Claudia. University of Tulane; Estados Unidos
dc.description.fil
Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.description.fil
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
dc.journal.title
Journal of Clinical Microbiology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/JCM.01062-21
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