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dc.contributor.author
Dave, Noopur
dc.contributor.author
Cetiner, Ugur
dc.contributor.author
Arroyo, Daniel
dc.contributor.author
Fonbuena, Joshua
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Tiwari, Megna
dc.contributor.author
Barrera, Patricia Andrea
dc.contributor.author
Lander, Noelia
dc.contributor.author
Anishkin, Andriy
dc.contributor.author
Sukharev, Sergei
dc.contributor.author
Jimenez, Veronica
dc.date.available
2022-10-24T19:33:03Z
dc.date.issued
2021-07
dc.identifier.citation
Dave, Noopur; Cetiner, Ugur; Arroyo, Daniel; Fonbuena, Joshua; Tiwari, Megna; et al.; A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in trypanosoma cruzi; eLife Sciences Publications; eLife; 10; 7-2021; 1-32
dc.identifier.uri
http://hdl.handle.net/11336/174639
dc.description.abstract
The causative agent of Chagas disease undergoes drastic morphological and biochemical modifications as it passes between hosts and transitions from extracellular to intracellular stages. The osmotic and mechanical aspects of these cellular transformations are not understood. Here we identify and characterize a novel mechanosensitive channel in Trypanosoma cruzi (TcMscS) belonging to the superfamily of small-conductance mechanosensitive channels (MscS). TcMscS is activated by membrane tension and forms a large pore permeable to anions, cations, and small osmolytes. The channel changes its location from the contractile vacuole complex in epimastigotes to the plasma membrane as the parasites develop into intracellular amastigotes. TcMscS knockout parasites show significant fitness defects, including increased cell volume, calcium dysregulation, impaired differentiation, and a dramatic decrease in infectivity. Our work provides mechanistic insights into components supporting pathogen adaptation inside the host, thus opening the exploration of mechanosensation as a prerequisite for protozoan infectivity.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
eLife Sciences Publications
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
TRYPANOSOMA CRUZI
dc.subject
MECHANOSENSATION
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CRISPR-CAS9
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INFECTIVITY
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Bioquímica y Biología Molecular
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in trypanosoma cruzi
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T00:28:53Z
dc.identifier.eissn
2050-084X
dc.journal.volume
10
dc.journal.pagination
1-32
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Dave, Noopur. California State University; Estados Unidos
dc.description.fil
Fil: Cetiner, Ugur. University of Maryland; Estados Unidos
dc.description.fil
Fil: Arroyo, Daniel. California State University; Estados Unidos
dc.description.fil
Fil: Fonbuena, Joshua. California State University; Estados Unidos
dc.description.fil
Fil: Tiwari, Megna. California State University; Estados Unidos
dc.description.fil
Fil: Barrera, Patricia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina
dc.description.fil
Fil: Lander, Noelia. University of Cincinnati; Estados Unidos
dc.description.fil
Fil: Anishkin, Andriy. University of Maryland; Estados Unidos
dc.description.fil
Fil: Sukharev, Sergei. University of Maryland; Estados Unidos
dc.description.fil
Fil: Jimenez, Veronica. California State University; Estados Unidos
dc.journal.title
eLife
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://elifesciences.org/articles/67449
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.7554/eLife.67449
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