Methodological approaches to investigate the effects of histamine receptor targeting compounds in preclinical models of breast cancer

Numerous studies demonstrated the pivotal role of histamine in breast cancer development and progression. This chapter aims to describe different preclinical breast cancer models, including in vitro soft agar clonogenic assay and in vivo chemically induced breast tumors in rats, human triple negative breast cancer (TNBC) xenograft, and murine TNBC syngeneic graft in mice. All these models could be useful and complementary to assess the role of histamine receptor ligands in breast cancer, which could originate advances in novel therapeutics to treat this disease. This chapter also describes the gold standard radiometric techniques to evaluate the activity of histamine metabolizing enzymes in breast cancer specimens.

Palabras clave: ALLOGRAFT , BREAST CANCER , CARCINOGENESIS , CLONOGENIC ASSAY , PROLIFERATION , SYNGENEIC MODEL , TUMOR GROWTH , XENOGENEIC MODEL , XENOGRAFT

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/174358

URL: https://link.springer.com/protocol/10.1007/978-1-4939-6843-5_12

DOI: https://doi.org/10.1007/978-1-4939-6843-5

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Capítulos de libros(BIOMED)
Capítulos de libros de INSTITUTO DE INVESTIGACIONES BIOMEDICAS

Capítulos de libros(OCA HOUSSAY)
Capítulos de libros de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Citación

Martinel Lamas, Diego José; Nicoud, Melisa Beatriz; Sterle, Helena Andrea; Cricco, Graciela Patricia; Martin, Gabriel Alejandro; et al.; Methodological approaches to investigate the effects of histamine receptor targeting compounds in preclinical models of breast cancer; Springer; 196; 12; 2017; 353-387

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