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dc.contributor.author
Pungitore, Carlos Rodolfo
dc.contributor.author
García, Celina E.
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Martín García, Victor Sotero
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Tonn, Carlos Eugenio
dc.date.available
2022-10-20T12:27:12Z
dc.date.issued
2012-11
dc.identifier.citation
Pungitore, Carlos Rodolfo; García, Celina E.; Martín García, Victor Sotero; Tonn, Carlos Eugenio; Inhibition of Taq DNA polymerase by iridoid aglycone derivates; C M B Association; Cellular and Molecular Biology; 58; supp; 11-2012; 1786-1790
dc.identifier.issn
0145-5680
dc.identifier.uri
http://hdl.handle.net/11336/174075
dc.description.abstract
Faithful replication of DNA molecules by DNA polymerases is essential for genome integrity and correct transmission of genetic information in all living organisms. DNA polymerases have recently emerged as important cellular targets for chemical intervention in the development of anti-cancer agents. Herein we report additional synthesis of simplified bicyclic aglycones of iridoids and their biological activity against Taq DNA polymerase with the object to find out some of the likely molecular targets implicated in the biological activity showed for this kind of compounds. The compounds 14, 33 and 34 showed inhibitory activity against Taq DNA polymerase with IC50 values of 13.47, 17.65 and 18.31 microMolar, respectively. These results would allow proposing to DNA polymerases as the molecular targets implicated in this bioactivity and enhance the iridoid aglycones as leader molecule to develop new drugs for cancer therapy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
C M B Association
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Iridoid aglycones
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DNA polymerases
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Natural products
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Biological activity
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Química Orgánica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
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Bioquímica y Biología Molecular
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Inhibition of Taq DNA polymerase by iridoid aglycone derivates
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-05-20T15:08:53Z
dc.journal.volume
58
dc.journal.number
supp
dc.journal.pagination
1786-1790
dc.journal.pais
Francia
dc.journal.ciudad
Poitiers
dc.description.fil
Fil: Pungitore, Carlos Rodolfo. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
dc.description.fil
Fil: García, Celina E.. Universidad de La Laguna; España
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Fil: Martín García, Victor Sotero. Universidad de La Laguna; España
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Fil: Tonn, Carlos Eugenio. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; Argentina
dc.journal.title
Cellular and Molecular Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1170/210
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/23137851/
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