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dc.contributor.author
Fernandez, Lucia Raquel
dc.contributor.author
Musikant, Alejandro Daniel
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Edreira, Martin Miguel
dc.date.available
2022-10-17T17:03:17Z
dc.date.issued
2021-03
dc.identifier.citation
Fernandez, Lucia Raquel; Musikant, Alejandro Daniel; Edreira, Martin Miguel; Naturally Occurring Alkaloids, Derivatives, and Semi-synthetic Modifications as Lead Compounds for the Development of New Anti-Trypanosoma cruzi Agents; Springer; Current Clinical Microbiology Reports; 8; 2; 3-2021; 68-86
dc.identifier.issn
2196-5471
dc.identifier.uri
http://hdl.handle.net/11336/173569
dc.description.abstract
Purpose of Review: Despite recent advances, Chagas disease is still a public health issue that requires more efforts in order to develop efficient and safe drugs. Plants and fungi are the main source for semi-synthetic natural-inspired new molecules to treat human illness. In the present work, we summarize the main findings of natural-derived and semi-synthetic alkaloids against Trypanosoma cruzi. Recent Findings: Over the last 10 years, at least seven alkaloids groups with structural modifications, including 130 molecules and almost 100 semi-synthetic compounds derived from natural alkaloids, including hybrids molecules, modifications of aliphatic chain extension, chemical groups, and heteroatoms, were analyzed for its toxicity over parasites and mammalian cells. Summary: According to the available data, there are a good number of promising natural and/or semi-synthetic alkaloids that would meet the criteria to become candidates in the drug discovery process against Trypanosoma cruzi parasites. Main scaffolds that deserve special attention are natural quinolones, isoquinolines, and semi-synthetic hybrids molecules.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALKALOIDS
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ANTIPARASITIC ACTIVITY
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SYNTHETIC MODIFICATIONS
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TRYPANOSOMA CRUZI
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Otros Tópicos Biológicos
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Naturally Occurring Alkaloids, Derivatives, and Semi-synthetic Modifications as Lead Compounds for the Development of New Anti-Trypanosoma cruzi Agents
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T00:30:24Z
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
68-86
dc.journal.pais
Suiza
dc.description.fil
Fil: Fernandez, Lucia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
dc.description.fil
Fil: Musikant, Alejandro Daniel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
dc.description.fil
Fil: Edreira, Martin Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
dc.journal.title
Current Clinical Microbiology Reports
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s40588-021-00163-x
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s40588-021-00163-x
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