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dc.contributor.author
Tack, Lloyd J. W.
dc.contributor.author
van der Straaten, Saskia
dc.contributor.author
Riedl, Stefan
dc.contributor.author
Springer, Alexander
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Holterhus, Paul Martin
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Hornig, Nadine C.
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Kolesinska, Zofia
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Niedziela, Marek
dc.contributor.author
Baronio, Federico
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Balsamo, Antonio
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Hannema, Sabine E.
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Nordenström, Anna
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Poyrazoglu, Sukran
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Darendeliler, Fatma F.
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Grinspon, Romina
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Rey, Rodolfo Alberto
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Aljuraibah, Fahad
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Bryce, Jillian
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Ahmed, Faisal
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Tadokoro Cuccaro, Rieko
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Hughes, Ieuan
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Guaragna Filho, Guilherme
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Maciel Guerra, Andrea T.
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Guerra Junior, Gil
dc.contributor.author
Cools, Martine
dc.date.available
2022-10-17T13:42:38Z
dc.date.issued
2021-10
dc.identifier.citation
Tack, Lloyd J. W.; van der Straaten, Saskia; Riedl, Stefan; Springer, Alexander; Holterhus, Paul Martin; et al.; Growth, puberty and testicular function in boys born small for gestational age with a nonspecific disorder of sex development; Wiley Blackwell Publishing, Inc; Clinical Endocrinology; 96; 2; 10-2021; 165-174
dc.identifier.issn
0300-0664
dc.identifier.uri
http://hdl.handle.net/11336/173450
dc.description.abstract
Objective: Being born small for gestational age (SGA) is frequently associated with unexplained disorders of sex development (nonspecific DSD) in boys. Little is known about their future growth, puberty and testicular function. Our objective is to determine the long-term endocrine outcome of boys born SGA who have a nonspecific DSD. Design: Boys with a nonspecific DSD born SGA and appropriate for GA (AGA) were retrieved through the International Disorders of Sex Development registry and retrospective data collected, based on a spreadsheet containing 102 items. Patients and Measurements: In total, 179 boys were included, of which 115 were born SGA and 64 were born AGA. Their growth and pubertal development were compared. Serum LH, FSH, testosterone, AMH and inhibin B levels in infancy and puberty were analysed to assess testicular function. Results: At 2 years of age, 30% of SGA boys had incomplete or absent catch-up growth. Boys born SGA also had higher LH during minipuberty and lower testosterone in stimulation tests (p = 0.037 and 0.040, respectively), as compared to boys born AGA. No differences were observed in timing or course of puberty or end-pubertal hormone levels. Conclusions: Almost one out of three SGA boys with a nonspecific DSD experiences insufficient catch-up growth. In addition, our data suggest dysfunction of infantile Leydig cells or altered regulation of the hypothalamic–pituitary–gonadal axis in SGA boys during childhood. Sex steroid production during puberty seems unaffected.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DISORDERS OF SEX DEVELOPMENT
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GROWTH AND DEVELOPMENT
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HYPOSPADIAS
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PUBERTY
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SMALL FOR GESTATIONAL AGE
dc.subject.classification
Endocrinología y Metabolismo
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Growth, puberty and testicular function in boys born small for gestational age with a nonspecific disorder of sex development
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-08-23T20:50:51Z
dc.journal.volume
96
dc.journal.number
2
dc.journal.pagination
165-174
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Tack, Lloyd J. W.. University of Ghent; Bélgica
dc.description.fil
Fil: van der Straaten, Saskia. University of Ghent; Bélgica
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Fil: Riedl, Stefan. Vienna University of Technology; Austria
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Fil: Springer, Alexander. Vienna University of Technology; Austria
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Fil: Holterhus, Paul Martin. No especifíca;
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Fil: Hornig, Nadine C.. No especifíca;
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Fil: Kolesinska, Zofia. Poznan University of Medical Sciences; Polonia
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Fil: Niedziela, Marek. Poznan University of Medical Sciences; Polonia
dc.description.fil
Fil: Baronio, Federico. No especifíca;
dc.description.fil
Fil: Balsamo, Antonio. No especifíca;
dc.description.fil
Fil: Hannema, Sabine E.. Leiden University; Países Bajos
dc.description.fil
Fil: Nordenström, Anna. Karolinska University Hospital; Suecia
dc.description.fil
Fil: Poyrazoglu, Sukran. Istanbul University; Turquía
dc.description.fil
Fil: Darendeliler, Fatma F.. Istanbul University; Turquía
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Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
dc.description.fil
Fil: Aljuraibah, Fahad. University of Glasgow; Reino Unido
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Fil: Bryce, Jillian. University of Glasgow; Reino Unido
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Fil: Ahmed, Faisal. University of Glasgow; Reino Unido
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Fil: Tadokoro Cuccaro, Rieko. University of Cambridge; Estados Unidos
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Fil: Hughes, Ieuan. University of Cambridge; Estados Unidos
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Fil: Guaragna Filho, Guilherme. Universidade Estadual de Campinas; Brasil
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Fil: Maciel Guerra, Andrea T.. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Guerra Junior, Gil. Universidade Estadual de Campinas; Brasil
dc.description.fil
Fil: Cools, Martine. University of Ghent; Bélgica
dc.journal.title
Clinical Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/cen.14614
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/cen.14614
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