Mostrar el registro sencillo del ítem
dc.contributor.author
Biurrun Manresa, José Alberto
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.contributor.author
Schliessbach, Jürg
dc.contributor.author
Vuilleumier, Pascal H.
dc.contributor.author
Müller, Monika
dc.contributor.author
Musshoff, Frank
dc.contributor.author
Stamer, Ulrike
dc.contributor.author
Stüber, Frank
dc.contributor.author
Arendt Nielsen, Lars
dc.contributor.author
Curatolo, Michele
dc.date.available
2022-10-17T12:27:59Z
dc.date.issued
2021-04
dc.identifier.citation
Biurrun Manresa, José Alberto; Schliessbach, Jürg; Vuilleumier, Pascal H.; Müller, Monika; Musshoff, Frank; et al.; Anti-nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double-blinded, placebo-controlled study; Wiley; European Journal of Pain; 4-2021; 1-34
dc.identifier.issn
1090-3801
dc.identifier.uri
http://hdl.handle.net/11336/173424
dc.description.abstract
Background: There is increasing evidence for oxytocin as a neurotransmitter in spinal nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal horn, where they activate GABA-ergic inhibitory interneurons. The present study tested whether the long-acting oxytocin-analogue carbetocin has anti-nociceptive effects in multi-modal experimental pain in humans. Methods: Twenty-five male volunteers received carbetocin 100 mcg and placebo (0.9% NaCl) on two different sessions in a randomized, double-blinded, cross-over design. Multi-modal quantitative sensory testing (QST) including a model of capsaicin-induced hyperalgesia and allodynia were performed at baseline and at 10, 60 and 120 min after drug administration. QST data were analysed using mixed linear and logistic regression models. Carbetocin plasma concentrations and oxytocin receptor genotypes were quantified and assessed in an exploratory fashion. Results: An anti-nociceptive effect of carbetocin was observed on intramuscular electrical temporal summation (estimated difference: 1.26 mA, 95% CI 1.01 to 1.56 mA, p =.04) and single-stimulus electrical pain thresholds (estimated difference: 1.21 mA, 95% CI 1.0 to 1.47 mA, p =.05). Furthermore, the area of capsaicin-induced allodynia was reduced after carbetocin compared to placebo (estimated difference: −6.5 cm2, 95% CI −9.8 to −3.2 cm2, p <.001). Conclusions: This study provides evidence of an anti-nociceptive effect of carbetocin on experimental pain in humans. Significance: This study provides evidence of the anti-nociceptive effect of intravenous administration of the oxytocin agonist carbetocin in healthy male volunteers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hyperalgesia
dc.subject
Interneurons
dc.subject
Oxytocin analogs
dc.subject
Spinal cord dorsal horn
dc.subject.classification
Neurociencias
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
Medicina Básica
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.title
Anti-nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double-blinded, placebo-controlled study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-14T14:12:28Z
dc.journal.pagination
1-34
dc.journal.pais
Países Bajos
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Biurrun Manresa, José Alberto. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
dc.description.fil
Fil: Schliessbach, Jürg. Bern University Hospital; Suiza
dc.description.fil
Fil: Vuilleumier, Pascal H.. Bern University Hospital; Suiza
dc.description.fil
Fil: Müller, Monika. Bern University Hospital; Suiza
dc.description.fil
Fil: Musshoff, Frank. No especifíca; . Bern University Hospital; Suiza
dc.description.fil
Fil: Stamer, Ulrike. Bern University Hospital; Suiza
dc.description.fil
Fil: Stüber, Frank. Bern University Hospital; Suiza
dc.description.fil
Fil: Arendt Nielsen, Lars. No especifíca;
dc.description.fil
Fil: Curatolo, Michele. University of Washington; Estados Unidos
dc.journal.title
European Journal of Pain
![Se ha confirmado la validez de este valor de autoridad por un usuario](/themes/CONICETDigital/images/authority_control/invisible.gif)
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1002/ejp.1781
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/ejp.1781
Archivos asociados