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dc.contributor.author
Sánchez, Francisco Javier
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dc.contributor.author
Gonzalez, Valeria A.
dc.contributor.author
Farrando, Martin
dc.contributor.author
Baigorria Jayat, Ariel O.
dc.contributor.author
Segovia Roldan, Margarita
dc.contributor.author
Garciá Mendívil, Laura
dc.contributor.author
Ordovás, Laura
dc.contributor.author
Prado, Natalia Jorgelina
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dc.contributor.author
Pueyo, Esther
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dc.contributor.author
Diez, Emiliano Raúl
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dc.date.available
2022-10-14T16:33:23Z
dc.date.issued
2021-03
dc.identifier.citation
Sánchez, Francisco Javier; Gonzalez, Valeria A.; Farrando, Martin; Baigorria Jayat, Ariel O.; Segovia Roldan, Margarita; et al.; Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients; Hindawi Publishing Corporation; Oxidative Medicine and Cellular Longevity; 2020; 3-2021; 1-14
dc.identifier.issn
1942-0994
dc.identifier.uri
http://hdl.handle.net/11336/173285
dc.description.abstract
Aging leads to structural and electrophysiological changes that increase the risk of postoperative atrial arrhythmias; however, noninvasive preoperative markers of atrial proarrhythmic conditions are still needed. This study is aimed at assessing whether interatrial dyssynchrony determined using two-dimensional speckle tracking echocardiography relates to proarrhythmic structural and functional remodeling. A cohort of 45 patients in sinus rhythm referred for cardiac surgery was evaluated by echocardiography and surface electrocardiogram the day before the intervention. Transmembrane potential, connexin, and potassium channel distribution, inflammatory, and nitrooxidative markers were measured from right atrial tissue obtained from patients. A difference greater than 40 milliseconds between right and left atrial free wall contraction confirmed the presence of interatrial dyssynchrony in 21 patients. No difference in relation with age, previous diseases, and 2-dimensional echocardiographic findings as well as average values of global longitudinal right and left atrial strain were found between synchronic and dyssynchronic patients. Postoperative atrial fibrillation incidence increased from 8.3% in the synchronic group to 33.3% in the dyssynchronic ones. P wave duration showed no difference between groups. Action potentials from dyssynchronous patients decreased in amplitude, maximal rate of depolarization, and hyperpolarized. Duration at 30% of repolarization increased, being markedly shorter at 90% of repolarization. Only the dyssynchronous group showed early and delayed afterdepolarizations. Atrial tissue of dyssynchronous patients displayed lateralization of connexin 40 and increased connexin 43 expression and accumulation of tumor necrosis factor-α in the intercalated disc. Tumor necrosis factor-α did not colocalize, however, with lateralized connexin 40. Nitroxidative marks and KATP channels increased perivascularly and in myocytes. Our results demonstrate that, as compared to a traditional surface electrocardiogram, the novel noninvasive echocardiographic evaluation of interatrial dyssynchrony provides a better identification of nonaged-related proarrhythmic atrial remodeling with increased susceptibility to postoperative atrial fibrillation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Hindawi Publishing Corporation
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ATRIAL DYSSYNCHRONY
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STRAIN ECHOCARDIOGRAPHY
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OXIDATIVE STRESS
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ARRHYTHMIA
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CARDIAC SURGERY
dc.subject.classification
Sistemas Cardíaco y Cardiovascular
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Atrial Dyssynchrony Measured by Strain Echocardiography as a Marker of Proarrhythmic Remodeling and Oxidative Stress in Cardiac Surgery Patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-20T18:48:04Z
dc.journal.volume
2020
dc.journal.pagination
1-14
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Sánchez, Francisco Javier. Universidad Nacional de Cuyo; Argentina. Clínica de Cuyo; Argentina
dc.description.fil
Fil: Gonzalez, Valeria A.. Gobierno de la Provincia de Mendoza. Hospital Luis Lagomaggiore.; Argentina
dc.description.fil
Fil: Farrando, Martin. Clínica de Cuyo; Argentina
dc.description.fil
Fil: Baigorria Jayat, Ariel O.. Clínica de Cuyo; Argentina
dc.description.fil
Fil: Segovia Roldan, Margarita. Universidad de Zaragoza; España
dc.description.fil
Fil: Garciá Mendívil, Laura. Universidad de Zaragoza; España
dc.description.fil
Fil: Ordovás, Laura. Universidad de Zaragoza; España. Fundación Agencia Aragonesa para la Investigación y el Desarrollo; España
dc.description.fil
Fil: Prado, Natalia Jorgelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Pueyo, Esther. Universidad de Zaragoza; España. Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina; España
dc.description.fil
Fil: Diez, Emiliano Raúl. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Oxidative Medicine and Cellular Longevity
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/omcl/2020/8895078/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1155/2020/8895078
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