Artículo
Tumorigenic effect mediated by ROS/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma
Garay, María Isabel
; Comba, Andrea
; Vara Messler, Marianela
; Barotto, Nelso Neri; Silva, Renata Alejandra; Repossi Marquez, Pablo Gaston
; Quiroga, Patricia Liliana; Mazzudulli, Gina María; Brunotto, Mabel Noemí; Pasqualini, María Eugenia
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
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Fecha de publicación:
08/2021
Editorial:
Elsevier Science Inc.
Revista:
Prostaglandins.
ISSN:
1098-8823
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The aim of this study was to investigate the in vivo and in vitro effects of dietary ω-6 and ω-3 polyunsaturated fatty acids (PUFAs) and their derivatives on the expression of TP53 and their relationship with cellular proliferation and death in a murine mammary adenocarcinoma model. BALB/c mice were divided in three diet groups: chia oil (ChO) rich in ω-3, corn oil (CO) rich in ω-6/ω-3 and safflower oil (SO) rich in ω-6 and subcutaneously inoculated with LMM3 mammary tumor cell line. Results demonstrated that diets with higher concentration of omega-6 PUFAs induced an increment of linoleic and arachidonic acid on tumor cell membranes increasing ROS liberation, 12(S)-HHT generation, TP53, Ki67 expression and cell proliferation. However, diets enriched with high content in omega-3 PUFAs induced higher tumor cell apoptosis and tumor infiltration of CD3+ lymphocytes, lowest cell viability and proliferation. Dietary omega-3 PUFAs nutritional intervention can be used as a potential preventative strategy to inhibit the molecular signaling pathways involved in the mammary tumor growth process as the TP53.
Palabras clave:
MAMMARY GLAND
,
DIETARY PUFAS
,
EICOSANOIDS
,
ROS
,
TP53
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Licencia
Identificadores
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Citación
Garay, María Isabel; Comba, Andrea; Vara Messler, Marianela; Barotto, Nelso Neri; Silva, Renata Alejandra; et al.; Tumorigenic effect mediated by ROS/eicosanoids and their regulation on TP53 expression in a murine mammary gland adenocarcinoma; Elsevier Science Inc.; Prostaglandins.; 155; 106564; 8-2021; 1-9
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