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dc.contributor.author
López Fontana, Gastón
dc.contributor.author
Rey Echalecu, Lara Sofía
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Santiano, Flavia Eliana
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López Fontana, José Rodrigo
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López Laur, José Daniel
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Zyla, Leila Ester
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Valdemoros, Paula
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Guerrero Gimenez, Martin Eduardo
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Fernandez Muñoz, Juan Manuel
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Gomez, Silvina Esther
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Bruna, Flavia Alejandra
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Guglielmi, Juan Manuel
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Caron, Ruben Walter
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López Fontana, Constanza Matilde
dc.date.available
2022-10-13T14:39:22Z
dc.date.issued
2021-04
dc.identifier.citation
López Fontana, Gastón; Rey Echalecu, Lara Sofía; Santiano, Flavia Eliana; López Fontana, José Rodrigo; López Laur, José Daniel; et al.; Changes in prolactin receptor location in prostate tumors; Iniestares; Archivos Españoles de Urología; 74; 4; 4-2021; 419-426
dc.identifier.issn
0004-0614
dc.identifier.uri
http://hdl.handle.net/11336/173012
dc.description.abstract
Introduction: Prolactin (PRL) binds its receptor (PRLR) and stimulates cell proliferation, differentiation and survival in prostate cancer (PCa) cell lines via STAT5a, MAPK and AKT. Objective: To evaluate the expression of PRL and PRLR in normal and tumor prostate tissues with different Gleason patterns. Methods: Samples of normal, benign prostatic hyperplasia and PCa with different Gleason patterns were selected from radical prostatectomy. The intensity, location and percentage of stained cells for PRL and PRLR were evaluated by Immunohistochemistry. Co-localization was observed by confocal microscopy. Results: PRL was expressed diffusely and with a mild intensity in the cytoplasm of normal and tumor prostate luminal cells. Its expression only augmented in the Gleason 3 pattern (p 0.0001). The immunostaining intensity and the percentage of positive cells for PRLR did not vary between normal and tumor tissues. However, the location of the PRLR was modified by the tumorigenic process. In non-tumor tissues, PRLR expression was mostly in plasma membrane in the apical zone of epithelial cells. In tumor tissues, it was expressed in intracellular vesicles. The co-localization of PRL and PRLR was demonstrated in normal and tumor tissues suggesting that PRL could be acting in an autocrine and paracrine manner. Conclusion: PRL and its receptor were present in the cytoplasm of the epithelial cells of the normal and tumor prostate gland. In tumor tissues, the change in the location and appearance of cryptic PRLRs that store PRL may keep active the different signaling pathways related to cell proliferation and survival.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Iniestares
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
PROLACTIN
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PROSTATE CANCER
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PROLACTIN RECEPTOR
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Changes in prolactin receptor location in prostate tumors
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-20T17:59:32Z
dc.identifier.eissn
1576-8260
dc.journal.volume
74
dc.journal.number
4
dc.journal.pagination
419-426
dc.journal.pais
España
dc.journal.ciudad
Madrid
dc.description.fil
Fil: López Fontana, Gastón. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Clinica Andina de Urología; Argentina
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Fil: Rey Echalecu, Lara Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Santiano, Flavia Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
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Fil: López Fontana, José Rodrigo. Clinica Andina de Urología; Argentina
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Fil: López Laur, José Daniel. Clinica Andina de Urología; Argentina
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Fil: Zyla, Leila Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Valdemoros, Paula. Laboratorio de Anatomía Patológica Vega Valdemoros; Argentina
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Fil: Guerrero Gimenez, Martin Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Fernandez Muñoz, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Gomez, Silvina Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Bruna, Flavia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Guglielmi, Juan Manuel. Clinica Andina de Urología; Argentina
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Fil: Caron, Ruben Walter. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: López Fontana, Constanza Matilde. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Archivos Españoles de Urología
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.aeurologia.com/EN/Y2021/V74/I4/419
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