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dc.contributor.author
Bisogno, Fabricio Román  
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Fernández, María del Rosario  
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Lassaletta, José María  
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de Gonzalo, Gonzalo  
dc.date.available
2022-10-13T13:58:19Z  
dc.date.issued
2021-01  
dc.identifier.citation
Bisogno, Fabricio Román; Fernández, María del Rosario; Lassaletta, José María; de Gonzalo, Gonzalo; Room temperature ionic liquids in asymmetric hetero-ene type reactions: Improving organocatalyst performance at lower temperatures; Molecular Diversity Preservation International; Molecules; 26; 2; 1-2021; 1-9  
dc.identifier.issn
1420-3049  
dc.identifier.uri
http://hdl.handle.net/11336/172965  
dc.description.abstract
Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity for the studied reactions. However, there are just a few examples of their use in hydrogen bonding organocatalysis. In this paper, we show the positive effect of a set of imidazole-based ionic liquids ([bmim]BF4 and [hmim]PF6 ) in the enantioselective addition of formaldehyde tert-butylhydrazone to prochiral α-keto esters catalyzed by a sugar-based chiral thiourea. Reactions performed in the presence of low percentages of RTILs led to an increase of the catalyst activity, thereby making possible to work at lower temperatures. Thus, the chiral tert-butyl azomethyl tertiary alcohols could be obtained with moderate to good conversions and higher enantioselectivities for most of the studied substrates when using up to 30 vol% of [hmim]PF6 as a cosolvent in processes performed in toluene.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Molecular Diversity Preservation International  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ASYMMETRIC CATALYSIS  
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ENE-TYPE REACTIONS  
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IONIC LIQUIDS  
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ORGANOCATALYSIS  
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SOLVENT ENGINEERING  
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TERTIARY ALCOHOLS  
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Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
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Ingeniería de Procesos Químicos  
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Ingeniería Química  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Room temperature ionic liquids in asymmetric hetero-ene type reactions: Improving organocatalyst performance at lower temperatures  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-09-21T23:36:04Z  
dc.journal.volume
26  
dc.journal.number
2  
dc.journal.pagination
1-9  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basilea  
dc.description.fil
Fil: Bisogno, Fabricio Román. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina  
dc.description.fil
Fil: Fernández, María del Rosario. Universidad de Sevilla; España  
dc.description.fil
Fil: Lassaletta, José María. Instituto de Investigaciones Químicas; España. Centro de Innovación en Química Avanzada; España  
dc.description.fil
Fil: de Gonzalo, Gonzalo. Universidad de Sevilla; España  
dc.journal.title
Molecules  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/26/2/355  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/molecules26020355