Artículo
Hyaluronic acid—dexamethasone nanoparticles for local adjunct therapy of lung inflammation
Cámara, Candelaria Inés
; Bertocchi, Laura; Ricci, Caterina; Bassi, Rosaria; Bianchera, Annalisa; Cantú, Laura F.; Ruggero, Bettini; Del Favero, Elena
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Fecha de publicación:
10/2021
Editorial:
Molecular Diversity Preservation International
Revista:
International Journal of Molecular Sciences
ISSN:
1422-0067
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The delivery of a dexamethasone formulation directly into the lung appears as an appro-priate strategy to strengthen the systemic administration, reducing the dosage in the treatment of lung severe inflammations. For this purpose, a hyaluronic acid-dexamethasone formulation was developed, affording an inhalable reconstituted nanosuspension suitable to be aerosolized. The physico-chemical and biopharmaceutical properties of the formulation were tested: size, stability, loading of the spray-dried dry powder, reconstitution capability upon redispersion in aqueous me-dia. Detailed structural insights on nanoparticles after reconstitution were obtained by light and X-ray scattering techniques. (1) The size of the nanoparticles, around 200 nm, is in the proper range for a possible engulfment by macrophages. (2) Their structure is of the core-shell type, hosting dex-amethasone nanocrystals inside and carrying hyaluronic acid chains on the surface. This specific structure allows for nanosuspension stability and provides nanoparticles with muco-inert proper-ties. (3) The nanosuspension can be efficiently aerosolized, allowing for a high drug fraction poten-tially reaching the deep lung. Thus, this formulation represents a promising tool for the lung administration via nebulization directly in the pipe of ventilators, to be used as such or as adjunct therapy for severe lung inflammation.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Cámara, Candelaria Inés; Bertocchi, Laura; Ricci, Caterina; Bassi, Rosaria; Bianchera, Annalisa; et al.; Hyaluronic acid—dexamethasone nanoparticles for local adjunct therapy of lung inflammation; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 22; 19; 10-2021; 1-18
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