Artículo
Doxycycline interferes with tau aggregation and reduces its neuronal toxicity
Medina, Luciana
; González Lizarraga, Maria Florencia
; Dominguez Meijide, Antonio; Ploper, Diego
; Parrales, Valeria; Sequeira, Sabrina
; Cima Omori, Maria Sol; Zweckstetter, Markus; del Bel Belluz Guimaraes, Elaine; Michel, Patrick Pierre; Outeiro, Tiago Fleming; Raisman Vozari, Rita; Chehin, Rosana Nieves
; Socias, Sergio Benjamin
Fecha de publicación:
22/03/2021
Editorial:
Frontiers Media
Revista:
Frontiers in Aging Neuroscience
ISSN:
1663-4365
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since doxycycline impacts α-synuclein aggregation and toxicity, herein we tested its effect on tau. We found that doxycycline reduces amyloid aggregation of the 2N4R and K18 isoforms of tau protein in a dose-dependent manner. Furthermore, in a cell free system doxycycline also prevents tau seeding and in cell culture reduces toxicity of tau aggregates. Overall, our results expand the spectrum of action of doxycycline against aggregation-prone proteins, opening novel perspectives for its repurposing as a disease-modifying drug for tauopathies.
Palabras clave:
ALZHEIMER'S DISEASE
,
DOXYCYCLINE
,
PROTEIN AGGREGATION
,
TAU
,
TAUOPATHIES
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Identificadores
Colecciones
Articulos (IMMCA)
Articulos de INSTITUTO DE INVESTIGACIONES EN MEDICINA MOLECULAR Y CELULAR APLICADA DEL BICENTENARIO
Articulos de INSTITUTO DE INVESTIGACIONES EN MEDICINA MOLECULAR Y CELULAR APLICADA DEL BICENTENARIO
Citación
Medina, Luciana; González Lizarraga, Maria Florencia; Dominguez Meijide, Antonio; Ploper, Diego; Parrales, Valeria; et al.; Doxycycline interferes with tau aggregation and reduces its neuronal toxicity; Frontiers Media; Frontiers in Aging Neuroscience; 13; 22-3-2021; 1-13
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