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Artículo

Hippocampal NMDA receptors and the previous experience effect on memory

Cercato, Magalí CeciliaIcon ; Colettis, Natalia ClaudiaIcon ; Snitcofsky, MarinaIcon ; Aguirre, Alejandra InésIcon ; Kornisiuk, Edgar ErnestoIcon ; Baez, Maria VeronicaIcon ; Jerusalinsky, Diana AliciaIcon
Fecha de publicación: 09/2014
Editorial: Elsevier
Revista: Journal of Physiology
ISSN: 0928-4257
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

N-methyl-D-aspartate receptors (NMDAR) are thought to be responsible for switching synaptic activity specific patterns into long-term changes in synaptic function and structure, which would support learning and memory. Hippocampal NMDAR blockade impairs memory consolidation in rodents, while NMDAR stimulation improves it. Adult rats that explored twice an open field (OF) before a weak though overthreshold training in inhibitory avoidance (IA), expressed IA long-term memory in spite of the hippocampal administration of MK-801, which currently leads to amnesia. Those processes would involve different NMDARs. The selective blockade of hippocampal GluN2B-containing NMDAR with ifenprodil after training promoted memory in an IA task when the training was weak, suggesting that this receptor negatively modulates consolidation. In vivo, after 1 h of an OF exposure-with habituation to the environment-, there was an increase in GluN1 and GluN2A subunits in the rat hippocampus, without significant changes in GluN2B. Coincidentally, in vitro, in both rat hippocampal slices and neuron cultures there was an increase in GluN2A-NMDARs surface expression at 30 min; an increase in GluN1 and GluN2A levels at about 1 h after LTP induction was also shown. We hypothesize that those changes in NMDAR composition could be involved in the “anti-amnesic effect” of the previous OF. Along certain time interval, an increase in GluN1 and GluN2A would lead to an increase in synaptic NMDARs, facilitating synaptic plasticity and memory; while then, an increase in GluN2A/GluN2B ratio could protect the synapse and the already established plasticity, perhaps saving the specific trace.
Palabras clave: Nmdar , Long Term Memory , Anti Amnesic Effect; , Ltp , Open Field , Inhibitory Avoidance , Glun2a , Glun1
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/17279
URL: http://www.sciencedirect.com/science/article/pii/S0928425714000357
DOI: http://dx.doi.org/10.1016/j.jphysparis.2014.08.001
Colecciones
Articulos(IBCN)
Articulos de INST.DE BIOLO.CEL.Y NEURCS."PROF.E.DE ROBERTIS"
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Cercato, Magalí Cecilia; Colettis, Natalia Claudia; Snitcofsky, Marina; Aguirre, Alejandra Inés; Kornisiuk, Edgar Ernesto; et al.; Hippocampal NMDA receptors and the previous experience effect on memory; Elsevier; Journal of Physiology; 108; 4-6; 9-2014; 263-269
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