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dc.contributor.author
Sebayang, Afrina Andriani
dc.contributor.author
Fahlena, Hilda
dc.contributor.author
Anam, Vizda
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Knopoff, Damián Alejandro
dc.contributor.author
Stollenwerk, Nico
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Aguiar, Maíra
dc.contributor.author
Soewono, Edy
dc.date.available
2022-10-12T18:08:12Z
dc.date.issued
2021-09-20
dc.identifier.citation
Sebayang, Afrina Andriani; Fahlena, Hilda; Anam, Vizda; Knopoff, Damián Alejandro; Stollenwerk, Nico; et al.; Modeling dengue immune responses mediated by antibodies: A qualitative study; Multidisciplinary Digital Publishing Institute; Biology; 10; 9; 20-9-2021; 1-18
dc.identifier.uri
http://hdl.handle.net/11336/172768
dc.description.abstract
Dengue fever is a viral mosquito-borne infection and a major international public health concern. With 2.5 billion people at risk of acquiring the infection around the world, disease severity is influenced by the immunological status of the individual, seronegative or seropositive, prior to natural infection. Caused by four antigenically related but distinct serotypes, DENV-1 to DENV-4, infection by one serotype confers life-long immunity to that serotype and a period of temporary cross-immunity (TCI) to other serotypes. The clinical response on exposure to a second serotype is complex with the so-called antibody-dependent enhancement (ADE) process, a disease augmentation phenomenon when pre-existing antibodies to previous dengue infection do not neutralize but rather enhance the new infection, used to explain the etiology of severe disease. In this paper, we present a minimalistic mathematical model framework developed to describe qualitatively the dengue immunological response mediated by antibodies. Three models are analyzed and compared: (i) primary dengue infection, (ii) secondary dengue infection with the same (homologous) dengue virus and (iii) secondary dengue infection with a different (heterologous) dengue virus. We explore the features of viral replication, antibody production and infection clearance over time. The model is developed based on body cells and free virus interactions resulting in infected cells activating antibody production. Our mathematical results are qualitatively similar to the ones described in the empiric immunology literature, providing insights into the immunopathogenesis of severe disease. Results presented here are of use for future research directions to evaluate the impact of dengue vaccines.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Multidisciplinary Digital Publishing Institute
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ANTIBODIES
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ANTIBODY-DEPENDENT ENHANCEMENT
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DENGUE FEVER
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IMMUNE RESPONSE
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VIRAL LOAD
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WITHIN-HOST MODELING
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Matemática Aplicada
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Matemáticas
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CIENCIAS NATURALES Y EXACTAS
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Epidemiología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Modeling dengue immune responses mediated by antibodies: A qualitative study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-19T16:06:43Z
dc.identifier.eissn
2079-7737
dc.journal.volume
10
dc.journal.number
9
dc.journal.pagination
1-18
dc.journal.pais
Suiza
dc.journal.ciudad
Basilea
dc.description.fil
Fil: Sebayang, Afrina Andriani. Institut Teknologi Bandung; Indonesia
dc.description.fil
Fil: Fahlena, Hilda. Institut Teknologi Bandung; Indonesia
dc.description.fil
Fil: Anam, Vizda. Basque Center For Applied Mathematics; España
dc.description.fil
Fil: Knopoff, Damián Alejandro. Basque Center For Applied Mathematics; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
dc.description.fil
Fil: Stollenwerk, Nico. Basque Center For Applied Mathematics; España. Universita degli Studi di Trento; Italia
dc.description.fil
Fil: Aguiar, Maíra. Basque Center For Applied Mathematics; España. Universita degli Studi di Trento; Italia
dc.description.fil
Fil: Soewono, Edy. Institut Teknologi Bandung; Indonesia
dc.journal.title
Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/biology10090941
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2079-7737/10/9/941
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