Artículo
Immunotherapy with SLPI over-expressing mammary tumor cells decreases tumor growth
Reiteri, Romina Macarena
; Amiano, Nicolás Oscar
; Costa, Maria Julieta
; Tateosian, Nancy Liliana
; Chuluyan, Hector Eduardo
Fecha de publicación:
06/2011
Editorial:
Springer Verlag Berlín
Revista:
Cancer Immunology Immunotherapy
ISSN:
0340-7004
e-ISSN:
1432-0851
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We have demonstrated previously that the inoculation of murine mammary tumor cells genetically modified to express high levels of secretory leukocyte protease inhibitor (2C1) do not develop tumors in immunocompetent mice and these cells are more prone to apoptosis than control cells. The aim of the present study was to evaluate the role of the adaptive immune response in the lack of tumor growth of 2C1 cells and the possibility of using these cells for immunotherapy. The s.c. administration of mock transfected F3II cells induces tumor in BALB/c and Nude mice. However, the inoculation of 2C1 cells develops tumor in Nude but not in BALB/c mice. The inoculation of mock transfected F3II cells to 2C1 immunized BALB/c mice by repeated administration of 2C1 cells (once a week for 3 weeks) developed significantly smaller tumors than those observed in non-immunized mice. Remarkably, survival of tumor-bearing immunized mice was higher than non-immunized animals. Herein, we demonstrate that an immunotherapy with SLPI over-expressing non-irradiated tumor cells which do not develop tumor in immunocompetent mice, partially restrain the tumor growth induced by F3II cells and increase the survival of the mice.
Palabras clave:
Immunotherapy
,
Slpi
,
Cancer
,
Mammary Tumor
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos(OCA CIUDAD UNIVERSITARIA)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA CIUDAD UNIVERSITARIA
Citación
Reiteri, Romina Macarena; Amiano, Nicolás Oscar; Costa, Maria Julieta; Tateosian, Nancy Liliana; Chuluyan, Hector Eduardo; Immunotherapy with SLPI over-expressing mammary tumor cells decreases tumor growth; Springer Verlag Berlín; Cancer Immunology Immunotherapy; 60; 6; 6-2011; 895-900
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