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dc.contributor.author
Errecalde, Carlos
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dc.contributor.author
Urzúa Pizarro, Natala Francisca
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dc.contributor.author
Prieto, G.
dc.contributor.author
Luders, C.
dc.contributor.author
Liboa, Rosendo Anibal
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dc.contributor.author
Gramaglia, Romina Andrea
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dc.date.available
2022-10-11T12:40:40Z
dc.date.issued
2021-01
dc.identifier.citation
Errecalde, Carlos; Urzúa Pizarro, Natala Francisca; Prieto, G.; Luders, C.; Liboa, Rosendo Anibal; et al.; Disposition and residues of marbofloxacin in eggs of laying hens; Medwin Publisher; Advances in Pharmacology & Clinical Trials; 6; 1; 1-2021; 1-7
dc.identifier.issn
2474-9214
dc.identifier.uri
http://hdl.handle.net/11336/172435
dc.description.abstract
Marbofloxacin belongs to the group of fluoroquinolones, used exclusively in domestic animals. This study was carried out with the purpose of studying the temporal disposition of marbofloxacin in edible compartments of the egg after administration of 1, 52 mg/kg of marbofloxacin in drinking water for 11 consecutive days in hens in posture peak and average weight of 1,91±0,25 kg. Birds were housed in individual cages under controlled light conditions, ambient temperature, relative humidity, water and balanced feed ad libitum. After the administration, eggs were collected daily and immediately separated into albumen and yolk, identified per bird/day and stored at-20°C until analysis. The preparative assay consisted in extraction of the analyte using 200 mg of yolk or albumen, as appropriate, in deionized water, homogenizing solution and enrofloxacin solution as internal standard. Separation and quantification were performed by HPLC by reverse phase isocratic elution with fluorescence detector, mobile phase composed of water, acetonitrile and triethylamine adjusted to pH 3. According to the peak areas of known concentrations, the concentrations of the test samples were calculated by simple linear regression. The established marbofloxacin levels are higher and more persistent in the yolk than in albumen, reaching 8 and 9 days, respectively. The disposition characteristics observed with marbofloxacin are compatible with the physico-chemical properties of the antimicrobial with the respective compartments of the egg and the time required for its formation. Data obtained from marbofloxacin depletion in egg compartments were analyzed using the EMEA WT 1.4 software and conjecturing a rigorous MRL (0,001 µg/kg), a withdrawal period of 13 and 17 days was estimated, for albumen and yolk, respectively.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Medwin Publisher
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
EGG
dc.subject
MARBOFLOXACIN
dc.subject
RESIDUES
dc.subject.classification
Producción Animal y Lechería
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dc.subject.classification
Producción Animal y Lechería
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Disposition and residues of marbofloxacin in eggs of laying hens
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T23:57:46Z
dc.journal.volume
6
dc.journal.number
1
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Míchigan
dc.description.fil
Fil: Errecalde, Carlos. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
dc.description.fil
Fil: Urzúa Pizarro, Natala Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Prieto, G.. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Luders, C.. Universidad Catolica de Temuco.; Chile
dc.description.fil
Fil: Liboa, Rosendo Anibal. Universidad Nacional de Río Cuarto; Argentina
dc.description.fil
Fil: Gramaglia, Romina Andrea. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados; Argentina
dc.journal.title
Advances in Pharmacology & Clinical Trials
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://medwinpublishers.com/APCT/volume.php?volumeId=369&issueId=1110
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