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dc.contributor.author
Blanchard, Benoit
dc.contributor.author
Heurtaux, Tony
dc.contributor.author
Garcia, Corina Ileana
dc.contributor.author
Moll, Natalia M.
dc.contributor.author
Caillava, Céline
dc.contributor.author
Grandbarbe, Luc
dc.contributor.author
Klosptein, Armelle
dc.contributor.author
Kerninon, Christophe
dc.contributor.author
Frah, Magali
dc.contributor.author
Coowar, Djalil
dc.contributor.author
Baron-van Evercooren, Anne
dc.contributor.author
Morga, Eleonora
dc.contributor.author
Heuschling, Paul
dc.contributor.author
Nait Oumesmar, Brahim
dc.date.available
2015-08-19T14:01:21Z
dc.date.issued
2013-07-10
dc.identifier.citation
Blanchard, Benoit; Heurtaux, Tony; Garcia, Corina Ileana; Moll, Natalia M.; Caillava, Céline; et al.; Tocopherol Derivative TFA-12 Promotes Myelin Repair in Experimental Models of Multiple Sclerosis; Society for Neuroscience; Journal of Neuroscience; 33; 28; 10-7-2013; 11633-11642
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/1723
dc.description.abstract
Multiple sclerosis (MS) is an inflammatory disease of the CNS that is associated with demyelination and axonal loss, resulting in severe neurological handicap. Current MS therapies mostly target neuroinflammation but have only a little impact on CNS myelin repair. Progress toward treatments that enhance remyelination would therefore represent major advances in MS treatment. Here, we examined the ability of TFA-12, a new synthetic compound belonging to tocopherol long-chain fatty alcohols, to promote oligodendrocyte regeneration and remyelination in experimental models of MS. We showed that TFA-12 significantly ameliorates neurological deficit and severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) in mice. Histological evaluation of mouse EAE spinal cords showed that TFA-12 treatment reduces inflammation, astrogliosis, and myelin loss. Additionally, we demonstrated that TFA-12 accelerates remyelination of focal demyelinated lesions induced by lysolecithin injections.Wealso found that this compound induces the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes through the inhibition of the Notch/Jagged1 signaling pathway. Altogether, our data provide important proof of principle indicating that TFA-12 could be a potential therapeutic compound for myelin repair in MS.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Tfa-12
dc.subject
Oligodendrocytes
dc.subject
Multiple Sclerosis
dc.subject
Myelin
dc.subject.classification
Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Medicina Critica y de Emergencia
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Tocopherol Derivative TFA-12 Promotes Myelin Repair in Experimental Models of Multiple Sclerosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1529-2401
dc.journal.volume
33
dc.journal.number
28
dc.journal.pagination
11633-11642
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Blanchard, Benoit. Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia; . Institut National de la Santé et de la Recherche Médicale; Francia
dc.description.fil
Fil: Heurtaux, Tony. Université du Luxembourg. Faculté des Sciences, de la Technologie et de la Communication. Laboratoire de Neurobiologie. Life Sciences Research Unit; Luxemburgo;
dc.description.fil
Fil: Garcia, Corina Ileana. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Química Medicinal; Argentina. Institut National de la Santé et de la Recherche Médicale; Francia. Universite Pierre et Marie Curie; Francia;
dc.description.fil
Fil: Moll, Natalia M.. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.description.fil
Fil: Caillava, Céline. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.description.fil
Fil: Grandbarbe, Luc. Université du Luxembourg. Faculté des Sciences, de la Technologie et de la Communication. Laboratoire de Neurobiologie. Life Sciences Research Unit; Luxemburgo;
dc.description.fil
Fil: Klosptein, Armelle. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.description.fil
Fil: Kerninon, Christophe. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.description.fil
Fil: Frah, Magali. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.description.fil
Fil: Coowar, Djalil. AxoGlia Therapeutics; Luxemburgo;
dc.description.fil
Fil: Baron-van Evercooren, Anne. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.description.fil
Fil: Morga, Eleonora. Université du Luxembourg. Faculté des Sciences, de la Technologie et de la Communication. Laboratoire de Neurobiologie. Life Sciences Research Unit; Luxemburgo;
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Fil: Heuschling, Paul. Université du Luxembourg. Faculté des Sciences, de la Technologie et de la Communication. Laboratoire de Neurobiologie. Life Sciences Research Unit; Luxemburgo;
dc.description.fil
Fil: Nait Oumesmar, Brahim. Institut National de la Santé et de la Recherche Médicale; . Universite Pierre et Marie Curie; Francia; . Centre National de la Recherche Scientifique. Unités Mixtes de Recherche; Francia;
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/doi:10.1523/JNEUROSCI.0774-13.2013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/33/28/11633.full.pdf+html
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