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Artículo

Iron oxide incorporated conjugated polymer nanoparticles for simultaneous use in magnetic resonance and fluorescent imaging of brain tumors

Arias Ramos, Nuria; Ibarra, Luis ExequielIcon ; Serrano Torres, María; Yagüe, Balbino; Caverzan, Matias DanielIcon ; Chesta, Carlos AlbertoIcon ; Palacios, Rodrigo EmilianoIcon ; López Larrubia, Pilar
Fecha de publicación: 08/2021
Editorial: Multidisciplinary Digital Publishing Institute
Revista: Pharmaceutics
e-ISSN: 1999-4923
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Físico-Química, Ciencia de los Polímeros, Electroquímica

Resumen

Conjugated polymer nanoparticles (CPNs) have emerged as advanced polymeric nanoplat-forms in biomedical applications by virtue of extraordinary properties including high fluorescence brightness, large absorption coefficients of one and two-photons, and excellent photostability and colloidal stability in water and physiological medium. In addition, low cytotoxicity, easy functional-ization, and the ability to modify CPN photochemical properties by the incorporation of dopants, convert them into excellent theranostic agents with multifunctionality for imaging and treatment. In this work, CPNs were designed and synthesized by incorporating a metal oxide magnetic core (Fe3 O4 and NiFe2 O4 nanoparticles, 5 nm) into their matrix during the nanoprecipitation method. This modification allowed the in vivo monitoring of nanoparticles in animal models using magnetic resonance imaging (MRI) and intravital fluorescence, techniques widely used for intracranial tumors evaluation. The modified CPNs were assessed in vivo in glioblastoma (GBM) bearing mice, both heterotopic and orthotopic developed models. Biodistribution studies were performed with MRI acquisitions and fluorescence images up to 24 h after the i.v. nanoparticles administration. The resulting IONP-doped CPNs were biocompatible in GBM tumor cells in vitro with an excellent cell incorporation depending on nanoparticle concentration exposure. IONP-doped CPNs were detected in tumor and excretory organs of the heterotopic GBM model after i.v. and i.t. injection. However, in the orthotopic GBM model, the size of the nanoparticles is probably hindering a higher effect on intratumorally T2-weighted images (T2 WI) signals and T2 values. The photodynamic therapy (PDT)—cytotoxicity of CPNs was not either affected by the IONPs incorporation into the nanoparticles.
Palabras clave: CONJUGATED POLYMER , GLIOBLASTOMA , IRON OXIDE NANOPARTICLES , MRI , NANOPARTICLES , PRECLINICAL TRIALS , THERANOSTIC
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/172382
DOI: http://dx.doi.org/10.3390/pharmaceutics13081258
URL: https://www.mdpi.com/1999-4923/13/8/1258
Colecciones
Articulos (IITEMA)
Articulos de INSTITUTO DE INVESTIGACIONES EN TECNOLOGIAS ENERGETICAS Y MATERIALES AVANZADOS
Articulos (INBIAS)
Articulos de INSTITUTO DE BIOTECNOLOGIA AMBIENTAL Y SALUD
Citación
Arias Ramos, Nuria; Ibarra, Luis Exequiel; Serrano Torres, María; Yagüe, Balbino; Caverzan, Matias Daniel; et al.; Iron oxide incorporated conjugated polymer nanoparticles for simultaneous use in magnetic resonance and fluorescent imaging of brain tumors; Multidisciplinary Digital Publishing Institute; Pharmaceutics; 13; 8; 8-2021; 1-21
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