Show simple item record Sales, Maria Elena 2017-05-31T21:41:20Z 2012-04
dc.identifier.citation Sales, Maria Elena; Tumor growth is stimulated by muscarinic receptors agonism: role of autoantibodies in breast cancer patients; Bentham Science Publishers; Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry; 12; 3; 4-2012; 208-215
dc.identifier.issn 1871-5222
dc.description.abstract In developed countries, cancer has replaced infectious diseases as a major cause of death. Currently, efforts in the immunoprevention of cancer are beginning to resemble those presented by the prevention of infectious diseases by immunization a century ago. Breast cancer is the most frequent type of tumor in women and is the second leading cause of death by this illness, among them. Moreover, cancer incidence will grow during next years. Some findings in autoimmunity related to breast cancer in animal models have been important to clarify mechanisms that potentiate tumor growth. Clinical and experimental data now clearly indicate that chronic inflammation significantly contributes to cancer development. Emerging out of these studies is an appreciation that persistent humoral immune responses exacerbate recruitment and activation of innate immune cells in the neoplastic microenvironment where they regulate tissue remodeling, pro-angiogenic and pro-survival pathways that together potentiate cancer development. Generally, antigens involved in autoimmune response in breast cancer are modified self-proteins or over-expressed normal proteins that induce autoantibodies (autoAbs) formation, which exhibit tumor promoting actions. Very frequently muscarinic acetylcholine receptors (mAChR) are up-regulated in different types of tumors appearing in different animal species. mAChR have the ability to act as autoantigens for tumor bearers. This article will review recent results concerning to the ability of mAChR expressed in transformed breast cells to trigger autoAbs formation either in experimental models or in breast cancer patients. We will also discuss the action of these antibodies as agonists of mAChR.
dc.format application/pdf
dc.language.iso eng
dc.publisher Bentham Science Publishers
dc.rights info:eu-repo/semantics/restrictedAccess
dc.subject Autoantibodies
dc.subject Muscarinic receptors
dc.subject Breast cancer
dc.subject Tumor growth
dc.subject MCF-7 T1N0Mx breast tumors
dc.subject Autoantigens
dc.subject Cells proliferation
dc.subject Inositol monophosphate
dc.subject Nitric oxide synthase
dc.subject Phospholipase Cβ2
dc.subject Protein kinase C
dc.subject Tumor progression
dc.subject.classification Otras Ciencias de la Salud
dc.subject.classification Ciencias de la Salud
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Tumor growth is stimulated by muscarinic receptors agonism: role of autoantibodies in breast cancer patients
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion 2017-05-31T20:03:52Z
dc.journal.volume 12
dc.journal.number 3
dc.journal.pagination 208-215
dc.journal.pais Emiratos Árabes Unidos
dc.journal.ciudad Sharjah
dc.description.fil Fil: Sales, Maria Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.journal.title Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/

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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)