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dc.contributor.author
Tateosian, Nancy Liliana
dc.contributor.author
Costa, Maria Julieta
dc.contributor.author
Guerrieri, Diego
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Barro, Analía
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Mazzei, Juan A.
dc.contributor.author
Chuluyan, Hector Eduardo
dc.date.available
2017-05-31T21:40:31Z
dc.date.issued
2012-06
dc.identifier.citation
Tateosian, Nancy Liliana; Costa, Maria Julieta; Guerrieri, Diego; Barro, Analía; Mazzei, Juan A.; et al.; Inflammatory mediators in exhaled breath condensate of healthy donors and exacerbated COPD patients; Elsevier; Cytokine.; 58; 3; 6-2012; 361-367
dc.identifier.issn
1043-4666
dc.identifier.uri
http://hdl.handle.net/11336/17233
dc.description.abstract
Samples of exhaled breath condensate (EBC) provide a convenient and non-invasive method to study inflammation in lung diseases. The aim of the present study was to evaluate and compare the inflammatory protein mediator levels in EBC from healthy donors (HD) and from patients with exacerbation of chronic obstructive pulmonary disease (COPD) using an EBC collection device with and without a coating of albumin as a carrier. We studied 13 HD and 26 patients with exacerbation of COPD. The concentrations of myeloperoxidase (MPO), IFNγ and secretory leukocyte protease inhibitor (SLPI) in EBC were measured by immunoassays. The EBC samples from HD and COPD patients showed higher concentrations of MPO when samples were recovered with an albumin-coated device. Furthermore, levels of MPO in COPD patients were significantly higher than in HD. An inverse correlation was observed between MPO and spirometric parameters (FVC and FEV1). Almost all samples collected with the albumin-coated device showed higher amounts of IFNγ and SLPI than those collected with the uncoated device. The levels of SLPI in COPD patients were significantly higher than in HD. A direct correlation was observed between FVC% predicted and SLPI. We concluded that coating the collection device with albumin increased the sensitivity of the technique, at least for measurements of MPO, SLPI and IFNγ. Furthermore, the higher levels of MPO and SLPI and lower levels of IFNγ in EBC from COPD patients could reflect the immunological status and the response of lung parenchyma to treatment during the exacerbation of the illness.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Copd
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Slpi
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Exhaled Breath Condensate
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Mpo
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Ifnγ
dc.subject.classification
Sistema Respiratorio
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Inflammatory mediators in exhaled breath condensate of healthy donors and exacerbated COPD patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-05-31T20:03:57Z
dc.journal.volume
58
dc.journal.number
3
dc.journal.pagination
361-367
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Tateosian, Nancy Liliana. UNIVERSIDAD DE BUENOS AIRES. FACULTAD DE MEDICINA. CÁTEDRA DE FARMACOLOGÍA. 3º CÁTEDRA DE FARMACOLOGÍA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Costa, Maria Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. UNIVERSIDAD DE BUENOS AIRES. FACULTAD DE MEDICINA. CÁTEDRA DE FARMACOLOGÍA. 3º CÁTEDRA DE FARMACOLOGÍA; Argentina
dc.description.fil
Fil: Guerrieri, Diego. UNIVERSIDAD DE BUENOS AIRES. FACULTAD DE MEDICINA. CÁTEDRA DE FARMACOLOGÍA. 3º CÁTEDRA DE FARMACOLOGÍA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Barro, Analía. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Mazzei, Juan A.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.description.fil
Fil: Chuluyan, Hector Eduardo. UNIVERSIDAD DE BUENOS AIRES. FACULTAD DE MEDICINA. CÁTEDRA DE FARMACOLOGÍA. 3º CÁTEDRA DE FARMACOLOGÍA; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Cytokine.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cyto.2012.03.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1043466612000890
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