Artículo
Memory reconsolidation as a tool to endure encoding deficits in elderly
Tassone, Leonela Magali
; Urreta Benitez, Facundo Antonio
; Rochon, Delfina; Martínez, Paula B.; Bonilla, Matías
; Leon, Candela S.; Muchnik, Carolina; Solis, Patricia Cristina Lourdes; Medel, Nancy Ruth; Kochen, Sara Silvia
; Brusco, Luis Ignacio
; Moyano, Malen Daiana
; Forcato, Cecilia
Fecha de publicación:
08/2020
Editorial:
Public Library of Science
Revista:
Plos One
ISSN:
1932-6203
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Normal aging involves changes in the ability to acquire, consolidate and recall new information. It has been recently proposed that the reconsolidation process is also affected in older adults. Reconsolidation is triggered after reminder presentation, allowing memories to be modified: they can be impaired, strengthened or changed in their content. In young adults it was previously shown that the presentation of repetitive reminders induces memory strengthening one day after reactivation and the presentation of at least one reminder increases memory persistence several days after reactivation. However, until now this process has remained elusive in older adults. We hypothesize that older adults need a stronger reminder to induce memory strengthening through the reconsolidation process than young adults. To test this, we perform a three-day experiment. On day 1, participants learned 15 sound-word associations, on day 2 they received no reminders (NR group), one reminder (R group) or two rounds of reactivations (Rx2 group). Finally, they were tested on day 7. We found that, contrary to our hypothesis, older adults show a memory improvement triggered by repeated labilization/reconsolidation processes to an equal extent than young adults. These results open new perspectives into the use of reconsolidation to improve daily acquired information and the development of therapeutic home used tools to produce memory enhancement in healthy older adults or those with cognitive decline.
Palabras clave:
MEMORY
,
RECONSOLIDATION
,
OLDER ADULTS
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Tassone, Leonela Magali; Urreta Benitez, Facundo Antonio; Rochon, Delfina; Martínez, Paula B.; Bonilla, Matías; et al.; Memory reconsolidation as a tool to endure encoding deficits in elderly; Public Library of Science; Plos One; 15; 8; 8-2020; 1-15
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