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dc.contributor.author
Stancampiano, Marianna R.  
dc.contributor.author
Lucas-Herald, Angela K.  
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Bryce, Jillian  
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Russo, Gianni  
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Barera, Graziano  
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Balsamo, Antonio  
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Baronio, Federico  
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Bertelloni, Silvano  
dc.contributor.author
Valiani, Margherita  
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Cools, Martine  
dc.contributor.author
Tack, Lloyd J.W.  
dc.contributor.author
Darendeliler, Feyza  
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Poyrazoglu, Sukran  
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Globa, Evgenia  
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Grinspon, Romina  
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Hannema, Sabine E.  
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Hughes, Ieuan A.  
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Tadokoro Cuccaro, Rieko  
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Thankamony, Ajay  
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Iotova, Violeta  
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Mladenov, Vilhelm  
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Konrad, Daniel  
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Mazen, Inas  
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Niedziela, Marek  
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Kolesinska, Zofia  
dc.contributor.author
Nordenström, Anna  
dc.contributor.author
Ahmed, S. Faisal  
dc.date.available
2022-10-06T09:19:28Z  
dc.date.issued
2021-07-07  
dc.identifier.citation
Stancampiano, Marianna R.; Lucas-Herald, Angela K.; Bryce, Jillian; Russo, Gianni; Barera, Graziano; et al.; Testosterone Therapy and Its Monitoring in Adolescent Boys with Hypogonadism: Results of an International Survey from the I-DSD Registry; Karger; Sexual Development; 15; 4; 7-7-2021; 236-243  
dc.identifier.issn
1661-5425  
dc.identifier.uri
http://hdl.handle.net/11336/172108  
dc.description.abstract
It is unclear whether testosterone replacement therapy (TRT) in adolescent boys, affected by a range of endocrine diseases that may be associated with hypogonadism, is particularly common. The aim of this study was to assess the contemporary practice of TRT in boys included in the I-DSD Registry. All participating centres in the I-DSD Registry that had boys between 10 and 18 years of age and with a condition that could be associated with hypogonadism were invited to provide further information in 2019. Information on 162 boys was collected from 15 centres that had a median (range) number of 6 boys per centre (1.35). Of these, 30 (19%) from 9 centres were receiving TRT and the median (range) age at the start was 12.6 years (10.8-16.2), with 6 boys (20%) starting at <12 years. Median (range) age of boys not on TRT was 11.7 years (10.7-17.7), and 69 out of 132 (52%) were <12 years. TRT had been initiated in 20 of 71 (28%) boys with a disorder of gonadal development, 3 of 14 (21%) with a disorder of androgen synthesis, and all 7 (100%) boys with hypogonadotropic hypogonadism. The remainder who did not have TRT included 15 boys with partial androgen insensitivity, 52 with non-specific XY DSD, and 3 with persistent Müllerian duct syndrome. Before starting TRT, liver function and blood count were checked in 19 (68%) and 18 boys (64%), respectively, a bone age assessment was performed in 23 (82%) and bone mineral density assessment in 12 boys (43%). This snapshot of contemporary practice reveals that TRT in boys included in the I-DSD Registry is not very common, whilst the variation in starting and monitoring therapy is quite marked. Standardisation of practice may lead to more effective assessment of treatment outcomes.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Karger  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ADOLESCENT BOYS  
dc.subject
DSD  
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HYPOGONADISM  
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TESTOSTERONE  
dc.subject.classification
Endocrinología y Metabolismo  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Testosterone Therapy and Its Monitoring in Adolescent Boys with Hypogonadism: Results of an International Survey from the I-DSD Registry  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2022-08-23T20:52:21Z  
dc.journal.volume
15  
dc.journal.number
4  
dc.journal.pagination
236-243  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Stancampiano, Marianna R.. University of Glasgow; Reino Unido  
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Fil: Lucas-Herald, Angela K.. University of Glasgow; Reino Unido  
dc.description.fil
Fil: Bryce, Jillian. University of Glasgow; Reino Unido  
dc.description.fil
Fil: Russo, Gianni. No especifíca;  
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Fil: Barera, Graziano. No especifíca;  
dc.description.fil
Fil: Balsamo, Antonio. No especifíca;  
dc.description.fil
Fil: Baronio, Federico. No especifíca;  
dc.description.fil
Fil: Bertelloni, Silvano. No especifíca;  
dc.description.fil
Fil: Valiani, Margherita. No especifíca;  
dc.description.fil
Fil: Cools, Martine. No especifíca;  
dc.description.fil
Fil: Tack, Lloyd J.W.. No especifíca;  
dc.description.fil
Fil: Darendeliler, Feyza. No especifíca;  
dc.description.fil
Fil: Poyrazoglu, Sukran. No especifíca;  
dc.description.fil
Fil: Globa, Evgenia. No especifíca;  
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Fil: Grinspon, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina  
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Fil: Hannema, Sabine E.. No especifíca;  
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Fil: Hughes, Ieuan A.. University of Cambridge; Estados Unidos  
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Fil: Tadokoro Cuccaro, Rieko. University of Cambridge; Estados Unidos  
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Fil: Thankamony, Ajay. University of Cambridge; Estados Unidos  
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Fil: Iotova, Violeta. No especifíca;  
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Fil: Mladenov, Vilhelm. No especifíca;  
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Fil: Konrad, Daniel. No especifíca;  
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Fil: Mazen, Inas. No especifíca;  
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Fil: Niedziela, Marek. No especifíca;  
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Fil: Kolesinska, Zofia. No especifíca;  
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Fil: Nordenström, Anna. No especifíca;  
dc.description.fil
Fil: Ahmed, S. Faisal. University of Glasgow; Reino Unido  
dc.journal.title
Sexual Development  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1159/000516784