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dc.contributor.author
Rojo, Macarena Gisele
dc.contributor.author
Cristos, Diego Sebastián
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González Patricia
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López Aca, Calixta Viviana
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Dománico, Ricardo Hugo
dc.contributor.author
Carriquiriborde, Pedro
dc.date.available
2022-10-06T02:40:05Z
dc.date.issued
2020-11
dc.identifier.citation
Rojo, Macarena Gisele; Cristos, Diego Sebastián; González Patricia; López Aca, Calixta Viviana; Dománico, Ricardo Hugo; et al.; Accumulation of human pharmaceuticals and activity of biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin; Pergamon-Elsevier Science Ltd; Chemosphere; 266; 129012; 11-2020; 1-7
dc.identifier.issn
0045-6535
dc.identifier.uri
http://hdl.handle.net/11336/172102
dc.description.abstract
The accumulation of four human pharmaceuticals active compounds (HPhAC) in the muscle of four fish species of the Rio de la Plata Basin were assessed regarding the compound logP and pKa, and fish trophic levels. For Prochilodus lineatus, accumulation was compared to hepatic biotransformation enzymes and fish from two sampling areas with different urbanization degree. Species were the detritivore Prochilodus lineatus, the omnivores Megaleporinus obtusidens and Pimelodus maculatus, and the piscivorous Salminus brasiliensis. Sampling areas were the Inner Rio de la Plata Estuary (RLP), in front of the Buenos Aires Metropolitan Area, and at the Lower Uruguay River (URU), a relatively unpopulated area. Carbamazepine, atenolol, enalapril, and sildenafil concentrations in fish muscle were analyzed by HPLC-MS. EROD, BROD, and GST activities were measured in P. lineatus liver. Average (maximum) concentrations and detection frequency were: Atenolol 24.4 (69.4) μg kg−1, 60%; carbamazepine 5.5 (45.8) μg kg−1, 19%; enalapril 7.0 (56.9) μg kg−1, 28%; sildenafil 17.1 (71.6) μg kg−1, 56%. Enalapril and sildenafil detection in fish was first-time reported. Atenolol and carbamazepine concentrations were positively correlated. No correlation was observed between HPhAC accumulation and logP or pKa. A potential biomagnification trend was observed for atenolol, showing higher accumulation in S. brasiliensis. HPhACs accumulation was higher for P. lineatus collected at URU, but GST and BROD were significantly higher for individuals sampled at RLP and were positively correlated. A significant negative correlation was observed for enalapril and BROD. The study contributes to the knowledge of the accumulation of HPhACs in fish.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
BIOACCUMULATION
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BIOTRANSFORMATION
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BUENOS AIRES METROPOLITAN AREA
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EMERGING POLLUTANTS
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TELEOSTEI
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Otras Ciencias de la Tierra y relacionadas con el Medio Ambiente
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Ciencias de la Tierra y relacionadas con el Medio Ambiente
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CIENCIAS NATURALES Y EXACTAS
dc.title
Accumulation of human pharmaceuticals and activity of biotransformation enzymes in fish from two areas of the lower Rio de la Plata Basin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-23T19:03:50Z
dc.journal.volume
266
dc.journal.number
129012
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Rojo, Macarena Gisele. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Cristos, Diego Sebastián. Instituto Nacional de Tecnología Agropecuaria; Argentina
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Fil: González Patricia. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina
dc.description.fil
Fil: López Aca, Calixta Viviana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
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Fil: Dománico, Ricardo Hugo. Comision Administradora del Rio Uruguay; Argentina
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Fil: Carriquiriborde, Pedro. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Química. Centro de Investigaciones del Medio Ambiente; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Chemosphere
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.chemosphere.2020.129012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0045653520332094
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