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dc.contributor.author
Slachevsky, Andrea
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Zitko, Pedro
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Martínez Pernía, David
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Forno, Gonzalo
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Court, Felipe A.
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Lillo, Patricia
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Villagra, Roque
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Duran Aniotz, Claudia
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Parrao, Teresa
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Assar, Rodrigo
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Orellana, Paulina
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Toledo, Carolina
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Rivera, Rodrigo
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Ibañez, Agustin Mariano
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Parra, Mario A.
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González Billault, Christian
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Amieva, Helena
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Thumala, Daniela
dc.date.available
2022-10-03T17:38:27Z
dc.date.issued
2020-12
dc.identifier.citation
Slachevsky, Andrea; Zitko, Pedro; Martínez Pernía, David; Forno, Gonzalo; Court, Felipe A.; et al.; GERO Cohort Protocol, Chile, 2017–2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly; BioMed Central; BMC Geriatrics; 20; 1; 12-2020; 1-13
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http://hdl.handle.net/11336/171535
dc.description.abstract
Background: With the global population aging and life expectancy increasing, dementia has turned a priority in the health care system. In Chile, dementia is one of the most important causes of disability in the elderly and the most rapidly growing cause of death in the last 20 years. Cognitive complaint is considered a predictor for cognitive and functional decline, incident mild cognitive impairment, and incident dementia. The GERO cohort is the Chilean core clinical project of the Geroscience Center for Brain Health and Metabolism (GERO). The objective of the GERO cohort is to analyze the rate of functional decline and progression to clinical dementia and their associated risk factors in a community-dwelling elderly with subjective cognitive complaint, through a population-based study. We also aim to undertake clinical research on brain ageing and dementia disorders, to create data and biobanks with the appropriate infrastructure to conduct other studies and facilitate to the national and international scientific community access to the data and samples for research. Methods: The GERO cohort aims the recruitment of 300 elderly subjects (> 70 years) from Santiago (Chile), following them up for at least 3 years. Eligible people are adults not diagnosed with dementia with subjective cognitive complaint, which are reported either by the participant, a proxy or both. Participants are identified through a household census. The protocol for evaluation is based on a multidimensional approach including socio-demographic, biomedical, psychosocial, neuropsychological, neuropsychiatric and motor assessments. Neuroimaging, blood and stool samples are also obtained. This multidimensional evaluation is carried out in a baseline and 2 follow-ups assessments, at 18 and 36 months. In addition, in months 6, 12, 24, and 30, a telephone interview is performed in order to keep contact with the participants and to assess general well-being. Discussion: Our work will allow us to determine multidimensional risks factors associated with functional decline and conversion to dementia in elderly with subjective cognitive complain. The aim of our GERO group is to establish the capacity to foster cutting edge and multidisciplinary research on aging in Chile including basic and clinical research. Trial registration: NCT04265482 in ClinicalTrials.gov. Registration Date: February 11, 2020. Retrospectively Registered.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
BioMed Central
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ALZHEIMER
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COGNITIVE AGING
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DEMENTIA
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FUNCTIONAL DECLINE
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GEROSCIENCE
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SUBJECTIVE COGNITIVE COMPLAINT
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
GERO Cohort Protocol, Chile, 2017–2022: Community-based Cohort of Functional Decline in Subjective Cognitive Complaint elderly
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-22T15:04:27Z
dc.identifier.eissn
1471-2318
dc.journal.volume
20
dc.journal.number
1
dc.journal.pagination
1-13
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Slachevsky, Andrea. Universidad del Desarrollo; Chile. Universidad de Chile; Chile. Geroscience Center For Brain Health And Metabolism; Chile
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Fil: Zitko, Pedro. Universidad de Chile; Chile. King's College London; Reino Unido. Geroscience Center For Brain Health And Metabolism; Chile
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Fil: Martínez Pernía, David. Geroscience Center For Brain Health And Metabolism; Chile. Universidad de Chile; Chile. Universidad Adolfo Ibañez; Chile
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Fil: Forno, Gonzalo. Geroscience Center For Brain Health And Metabolism; Chile. Universidad de Chile; Chile
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Fil: Court, Felipe A.. Geroscience Center For Brain Health And Metabolism; Chile. Universidad Mayor; Chile. The Buck Institute for Research on Aging; Estados Unidos
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Fil: Lillo, Patricia. Universidad de Chile; Chile. Geroscience Center For Brain Health And Metabolism; Chile. Hospital San Jose; Chile
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Fil: Villagra, Roque. Geroscience Center For Brain Health And Metabolism; Chile. Universidad de Chile; Chile
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Fil: Duran Aniotz, Claudia. Universidad Adolfo Ibañez; Chile
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Fil: Parrao, Teresa. Geroscience Center For Brain Health And Metabolism; Chile. Universidad Alberto Hurtado; Chile
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Fil: Assar, Rodrigo. Geroscience Center For Brain Health And Metabolism; Chile. Universidad de Chile; Chile
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Fil: Orellana, Paulina. Geroscience Center For Brain Health And Metabolism; Chile
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Fil: Toledo, Carolina. Geroscience Center For Brain Health And Metabolism; Chile
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Fil: Rivera, Rodrigo. Instituto de Neurocirugia Asenjo; Chile
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Fil: Ibañez, Agustin Mariano. Geroscience Center For Brain Health And Metabolism; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentina. Universidad Autónoma del Caribe; Colombia. University of California; Estados Unidos. Universidad Adolfo Ibañez; Chile
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Fil: Parra, Mario A.. Universidad Autónoma del Caribe; Colombia. University of Strathclyde; Reino Unido
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Fil: González Billault, Christian. Universidad de Chile; Chile. Geroscience Center For Brain Health And Metabolism; Chile. The Buck Institute for Research on Aging; Estados Unidos
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Fil: Amieva, Helena. Universite de Bordeaux; Francia
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Fil: Thumala, Daniela. Universidad de Chile; Chile. Geroscience Center For Brain Health And Metabolism; Chile
dc.journal.title
BMC Geriatrics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1186/s12877-020-01866-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-020-01866-4
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