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dc.contributor.author
Rupil, Lucia  
dc.contributor.author
Serradell, Marianela del Carmen.  
dc.contributor.author
Lujan, Hugo Daniel  
dc.contributor.other
Sunil, Thomas  
dc.date.available
2022-09-30T15:38:20Z  
dc.date.issued
2022  
dc.identifier.citation
Rupil, Lucia; Serradell, Marianela del Carmen.; Lujan, Hugo Daniel; Production of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins; Springer Nature Switzerland AG; 2410; 2022; 503-537  
dc.identifier.isbn
978-1-07-161883-7  
dc.identifier.uri
http://hdl.handle.net/11336/171250  
dc.description.abstract
Giardia lamblia is the only known parasite that can inhabit the harsh upper gastrointestinal tract, wheremost of the digestive proteases are secreted. Intestinal and free-living protozoa express surface proteinscontaining an extraordinarily high percentage of cysteine. These cysteine-rich variant-specific surfaceproteins (VSPs) form a dense coat on the entire surface of Giardia trophozoites, that coat protects theparasite inside the host intestine. VSPs not only are resistant to proteolytic digestion, extreme pH andtemperatures, but also stimulate host immune responses. These properties can be used to protect as well asto increase the immunogenicity of vaccine antigens for oral administration. The incorporation of VSPs ontovirus-like particles bearing viral antigens allows oral administration of these vaccines, protecting theantigens from degradation and generating robust and protective immune responses. In this chapter wedescribe the development of this versatile vaccine platform for the generation of safe, stable, and efficientoral vaccines, including their production and validation, as well as the characterization of immune responseto oral immunization.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer Nature Switzerland AG  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ORAL VACCINES  
dc.subject
VIRUS LIKE PARTICLES  
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GIARDIA LAMBLIA  
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VARIANT SPECIFIC SURFACE PROTEINS  
dc.subject.classification
Enfermedades Infecciosas  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Production of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2022-09-29T15:46:03Z  
dc.journal.volume
2410  
dc.journal.pagination
503-537  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Rupil, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Serradell, Marianela del Carmen.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina  
dc.description.fil
Fil: Lujan, Hugo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/book/10.1007/978-1-0716-1884-4?page=2#toc  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-0716-1884-4_26  
dc.conicet.paginas
711  
dc.source.titulo
Vaccine Design: Methods and Protocols. Vaccines for Human Diseases