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dc.contributor.author
Rupil, Lucia
dc.contributor.author
Serradell, Marianela del Carmen.
dc.contributor.author
Lujan, Hugo Daniel
dc.contributor.other
Sunil, Thomas
dc.date.available
2022-09-30T15:38:20Z
dc.date.issued
2022
dc.identifier.citation
Rupil, Lucia; Serradell, Marianela del Carmen.; Lujan, Hugo Daniel; Production of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins; Springer Nature Switzerland AG; 2410; 2022; 503-537
dc.identifier.isbn
978-1-07-161883-7
dc.identifier.uri
http://hdl.handle.net/11336/171250
dc.description.abstract
Giardia lamblia is the only known parasite that can inhabit the harsh upper gastrointestinal tract, wheremost of the digestive proteases are secreted. Intestinal and free-living protozoa express surface proteinscontaining an extraordinarily high percentage of cysteine. These cysteine-rich variant-specific surfaceproteins (VSPs) form a dense coat on the entire surface of Giardia trophozoites, that coat protects theparasite inside the host intestine. VSPs not only are resistant to proteolytic digestion, extreme pH andtemperatures, but also stimulate host immune responses. These properties can be used to protect as well asto increase the immunogenicity of vaccine antigens for oral administration. The incorporation of VSPs ontovirus-like particles bearing viral antigens allows oral administration of these vaccines, protecting theantigens from degradation and generating robust and protective immune responses. In this chapter wedescribe the development of this versatile vaccine platform for the generation of safe, stable, and efficientoral vaccines, including their production and validation, as well as the characterization of immune responseto oral immunization.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Nature Switzerland AG
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ORAL VACCINES
dc.subject
VIRUS LIKE PARTICLES
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GIARDIA LAMBLIA
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VARIANT SPECIFIC SURFACE PROTEINS
dc.subject.classification
Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Production of Oral Vaccines Based on Retrovirus Virus-like Particles Pseudotyped with Protozoan-Surface Proteins
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2022-09-29T15:46:03Z
dc.journal.volume
2410
dc.journal.pagination
503-537
dc.journal.pais
Suiza
dc.description.fil
Fil: Rupil, Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Serradell, Marianela del Carmen.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
dc.description.fil
Fil: Lujan, Hugo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas. Universidad Católica de Córdoba. Centro de Investigación y Desarrollo en Inmunología y Enfermedades Infecciosas; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/book/10.1007/978-1-0716-1884-4?page=2#toc
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-0716-1884-4_26
dc.conicet.paginas
711
dc.source.titulo
Vaccine Design: Methods and Protocols. Vaccines for Human Diseases
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