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dc.contributor.author
Luquita, A.  
dc.contributor.author
Urli, L.  
dc.contributor.author
Svetaz, M. J.  
dc.contributor.author
Gennaro, Ana Maria  
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Volpintesta, R.  
dc.contributor.author
Palatnik, S.  
dc.contributor.author
Rasia, M.  
dc.date.available
2017-05-30T19:35:05Z  
dc.date.issued
2009-10  
dc.identifier.citation
Luquita, A.; Urli, L.; Svetaz, M. J.; Gennaro, Ana Maria; Volpintesta, R.; et al.; Erythrocyte aggregation in rheumatoid arthritis: cell and plasma factor’s role; Ios Press; Clinical Hemorheology And Microcirculation; 41; 1; 10-2009; 49-56  
dc.identifier.issn
1386-0291  
dc.identifier.uri
http://hdl.handle.net/11336/17122  
dc.description.abstract
ncrease in erythrocyte aggregation (EA) is pathognomonic for rheumatoid arthritis (RA), and its estimation through erythrocyte sedimentation rate (ESR) is part of DAS 28-4 activity diagnosis, with low correlation with EA and that does not discriminate the contribution of cell factors that increase aggregation. Objective: To analyse cell and plasma factors that might be involved in EA increase, to understand how RA affects blood components, thus modifying blood fluid behavior. Methodology: One hundred women presenting active RA were compared with age-matched controls (C). EA was measured by transmitted light, obtaining two parameters: 2k2n0, characterizing the aggregation process kinetics and s0/n0, estimating aggregates size. Cell factors assays: erythrocyte deformability, by filtration through nucleopore membranes, cell shape, by microscopy, and membrane fluidity by EPR. Plasma: total proteins and CRP, albumin, fibrinogen (Fb), by gravimetry, and IgG and IgM by single radial immuno-diffusion. Results: AR and C (x ± SE). 2k2n0: 31.83 ± 2.84, 23.75 ± 1.91; s0/n0: 0.92 ± 0.05, 0.87 ± 0.04. Rigidity index (RI): 14.79 ± 4.71, 6.92 ± 1.31. Morphological index: 0.28 ± 0.03, 0.30 ± 0.05, n.s. Fb (mg/dl): 382 ± 80, 299 ± 70. IgG (mg/dl): 1580 ± 219, 1296 ± 158; IgM (mg/dl) 233 ± 28, 183 ± 23; albumin (g/dl) 3.84 ± 0.44, 3.77 ± 0.51 n.s. p < 0.05 accepted. Correlations: 2k2n0 vs. Fb r = 0.66; s0/n0 vs. Fb r = 0.51; 2k2n0 vs. Igs r = 0.65; s0/n0 vs. Igs r = 0.56. 2k2n0 vs. RI r = -0.59; s0/n0 vs. RI = -0.52, p < 0.05. Conclusions: Plasma factors, Igs and Fb increased aggregation, since RI is altered, this reduces the process efficiency regarding aggregation. Patients with active RA present an increased EA, with values modifications associated with the activity index DAS 28-4, thus becoming an RA activity indicator.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Ios Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Rheumatoid Arthritis Activity  
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Erythrocyte Aggregation  
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Membrane Fluidity  
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Erythrocyte Deformability  
dc.subject.classification
Biofísica  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Erythrocyte aggregation in rheumatoid arthritis: cell and plasma factor’s role  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-05-22T14:03:09Z  
dc.journal.volume
41  
dc.journal.number
1  
dc.journal.pagination
49-56  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Luquita, A.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Urli, L.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Svetaz, M. J.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Gennaro, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina  
dc.description.fil
Fil: Volpintesta, R.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Palatnik, S.. Universidad Nacional de Rosario; Argentina  
dc.description.fil
Fil: Rasia, M.. Universidad Nacional de Rosario; Argentina  
dc.journal.title
Clinical Hemorheology And Microcirculation  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch1154