Artículo
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311). Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).
Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
Título:
Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
Fernandez, Silvina; Fernandez, Silvina; de Vedia, Luis Alberto; de Vedia, Luis Alberto; Lopez Furst, M, J.; Lopez Furst, M, J.; Gardella, Noella Mariel; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia
; Di Gregorio, Sabrina Noelia
; Ganaha, M. C.; Ganaha, M. C.; Prieto, S.; Prieto, S.; Carbone, E.; Carbone, E.; Lista, N.; Lista, N.; Rotrying, F.; Rotrying, F.; Stryjewski, M. D.; Stryjewski, M. D.; Mollerach, Marta Eugenia
; Mollerach, Marta Eugenia
Fecha de publicación:
20/01/2013
20/01/2013
20/01/2013
Editorial:
Elsevier
Elsevier
Elsevier
Revista:
Infection, Genetics and Evolution
Infection, Genetics and Evolution
Infection, Genetics and Evolution
ISSN:
1567-1348
1567-1348
1567-1348
Idioma:
Inglés
Inglés
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
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Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Citación
Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405
Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405
Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405
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