Artículo
Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization
Gottardo, María Florencia
; Capobianco, Carla Sabrina
; Sidabra, Johanna Elena
; Garona, Juan
; Perera, Yasser; Perea, Silvio E.; Alonso, Daniel Fernando
; Farina, Hernán Gabriel
Fecha de publicación:
07/09/2020
Editorial:
Nature
Revista:
Scientific Reports
ISSN:
2045-2322
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
CK2 is a serine/threonine kinase that is overexpressed in breast cancer and its inhibition is associated to reduced tumor growth and disease progression. CIGB-300 is an antitumor peptide with a novel mechanism of action, since it binds to protein kinase CK2 catalytic subunit alpha and to CK2 substrates thus preventing the enzyme activity. Our aim was to evaluate the potential therapeutic benefits of CIGB-300 on breast cancer disease using experimental models with translational relevance. We demonstrated that CIGB-300 reduces breast cancer cell growth in MDA-MB-231, MCF-7 and F3II cells, exerting a pro-apoptotic action and cell cycle arrest. We also found that CIGB-300 decreased cell adhesion, migration and clonogenic capacity of malignant cells. Effect on experimental breast cancer lung metastasis was evaluated after surgical removal of primary F3II tumors or after tail vein injection of tumor cells, also we evaluated CIGB-300 effect on spontaneous lung metastasis in an orthotopic model. Systemic CIGB-300 treatment inhibited breast cancer colonization of the lung, reducing the size and number of metastatic lesions. The present preclinical study establishes for the first time the efficacy of CIGB-300 on breast cancer. These encouraging results suggest that CIGB-300 could be used for the management of breast cancer as an adjuvant therapy after surgery, limiting tumor metastatic spread and thus protecting the patient from distant recurrence.
Palabras clave:
METASTASIS
,
CK2
,
CIGB-300
,
BREAST CANCER
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Gottardo, María Florencia; Capobianco, Carla Sabrina; Sidabra, Johanna Elena; Garona, Juan; Perera, Yasser; et al.; Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization; Nature; Scientific Reports; 10; 1; 7-9-2020; 1-11
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