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Artículo

Ghrelin restores memory impairment following olfactory bulbectomy in mice by activating hippocampal NMDA1 and MAPK1 gene expression

Bianconi, SantiagoIcon ; Poretti, María BelénIcon ; Rodríguez, PaulaIcon ; Maestri, Giulia; Rodriguez, Pamela ElizabethIcon ; Rubiales de Barioglio, Susana; Schiöth, Helgi Birgir; Carlini, Valeria PaolaIcon
Fecha de publicación: 23/07/2021
Editorial: Elsevier Science
Revista: Behavioural Brain Research
ISSN: 0166-4328
e-ISSN: 1872-7549
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

Ghrelin (Ghrl) is an orexigenic peptide with potential roles in the modulation of anxiety- and depressive-like symptoms induced by bilateral olfactory bulbectomy (OB) in rodents. In the present work, we assessed whether intrahippocampal Ghrl could reverse OB-induced depressive-like and amnesic effects by regulating molecular mechanisms related to neuroplasticity. Adult female albino Swiss mice were divided into sham and OB groups, and infused with saline (S) or Ghrl 0.03 nmol/μl, 0.3 nmol/μl, or 3 nmol/μl into the hippocampus before exposition to open-field test (OFT) and tail suspension test (TST) or immediately after training in the object recognition test (ORT). After test phase in ORT, animals were euthanized and their hippocampi were dissected to study the expression of genes related to memory. The OB-S animals presented hyperlocomotion in OFT, increased immobility in TST and memory impairment compared to sham-S (p < 0.05), but acute intrahippocampal infusion of Ghrl 0.3 nmol/μl produced an improvement on these parameters in OB animals (p < 0.05). In addition, this dose of Ghrl reversed OB-induced low expression of NMDA1 and MAPK1 iso1 and up-regulated the expression of CaMKIIa iso1 and iso2, and MAPK1 iso2 (p < 0.05). These results extend the existing literature regarding OB-induced behavioral and neurochemical changes, and provide mechanisms that could underlie the antidepressant effect of Ghrl in this model.
Palabras clave: DEPRESSION , GHRELIN , MAPK/ERK2 , NMDA , OBJECT RECOGNITION MEMORY , OLFACTORY BULBECTOMY
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/170865
URL: https://www.sciencedirect.com/science/article/pii/S0166432821002291
DOI: http://dx.doi.org/10.1016/j.bbr.2021.113341
Colecciones
Articulos(INICSA)
Articulos de INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Citación
Bianconi, Santiago; Poretti, María Belén; Rodríguez, Paula; Maestri, Giulia; Rodriguez, Pamela Elizabeth; et al.; Ghrelin restores memory impairment following olfactory bulbectomy in mice by activating hippocampal NMDA1 and MAPK1 gene expression; Elsevier Science; Behavioural Brain Research; 410; 113341; 23-7-2021; 1-11
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