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dc.contributor.author
García, Juan Agustín
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dc.contributor.author
Rosas, Juan E.
dc.contributor.author
García y Santos, Carmen
dc.contributor.author
Streitenberger, Nicolás
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dc.contributor.author
Feijoo, Matías
dc.contributor.author
Dutra, Fernando
dc.date.available
2022-09-27T20:17:38Z
dc.date.issued
2020-01
dc.identifier.citation
García, Juan Agustín; Rosas, Juan E.; García y Santos, Carmen; Streitenberger, Nicolás; Feijoo, Matías; et al.; Senecio spp. transboundary introduction and expansion affecting cattle in Uruguay: Clinico-pathological, epidemiological and genetic survey, and experimental intoxication with Senecio oxyphyllus; Pergamon-Elsevier Science Ltd; Toxicon; 173; 1-2020; 68-74
dc.identifier.issn
0041-0101
dc.identifier.uri
http://hdl.handle.net/11336/170702
dc.description.abstract
The genus Senecio is distributed worldwide, being responsible of poisoning in livestock and humans. Many species of Senecio have high invasion and expansion capacity, highly competitive with agricultural and native plant species, causing ecological damage. Particularly in Uruguay, poisoning by Senecio have grown exponentially to reach epidemic proportions. Herein we describe Seneciosis as a re-emerging and expanding epidemic disease affecting cattle, by describing clinico-pathological, epidemiological and genetic variation of species involved, as well as an experimental intoxication with Senecio oxyphyllus. For this, a study was carried out on 28 cattle farms in Eastern Uruguay, with history of seneciosis from 2010 to 2016. Plants of fifty populations of Senecio were sampled, in 2015 and 2016, for identification, analysis of alkaloids and study of genetic variation. In turn, post-mortem examination was performed in cattle of natural and an experimental case to confirm the intoxication, showing microscopic characteristic lesions (hepatomegalocytosis, diffuse fibrosis and ductal reaction). Four species of Senecio were identified: S. oxyphyllus, S. madagascariensis, S. selloi and S. brasiliensis. In the genetic study, 489 molecular markers of amplified sequence-related polymorphisms (SRAP), associated with species and pasture, were used for genetic variation analysis. There was no statistically significant association between genetic variation determined by molecular markers and population (specimens of same species collected from the same farm), botanically determined species, or geographical origin. The increase of seneciosis in cattle in the last years, the presence of species not identified to the moment with implication in the poisoning outbreaks and expansion of these plants shows that the disease is in an epidemic growing active stage. In turn, the experimental poisoning with S. oxyphyllus confirms its chronic hepatotoxic effect, being an emergent species for the region, of high distribution and toxic risk. This latter turned out the main Senecio species involved. This case of expansion of harmful plant for animal production and desirable plant species, can be useful as a model of ecopathological characterization, which is likely to occur with other toxic plants in different geographical ranges globally.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ECOLOGICAL DISTURBANCE
dc.subject
GENOMIC DIVERGENCE
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HEPATOTOXICITY
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PLANT INVASION
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RUMINANTS
dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Senecio spp. transboundary introduction and expansion affecting cattle in Uruguay: Clinico-pathological, epidemiological and genetic survey, and experimental intoxication with Senecio oxyphyllus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-16T20:42:34Z
dc.journal.volume
173
dc.journal.pagination
68-74
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: García, Juan Agustín. Universidad de la Republica. Centro Universitario Regional del Este. Sede Universitaria de Treinta y Tres; Uruguay. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Rosas, Juan E.. Instituto Nacional de Investigación Agropecuaria; Uruguay
dc.description.fil
Fil: García y Santos, Carmen. Universidad de la Republica. Facultad de Veterinaria.; Uruguay
dc.description.fil
Fil: Streitenberger, Nicolás. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Cátedra de Patología Especial; Argentina
dc.description.fil
Fil: Feijoo, Matías. Universidad de la Republica. Centro Universitario Regional del Este. Sede Universitaria de Treinta y Tres; Uruguay
dc.description.fil
Fil: Dutra, Fernando. DILAVE “Miguel C Rubino” Regional Este; Uruguay
dc.journal.title
Toxicon
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.toxicon.2019.11.013
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0041010119307548
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