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dc.contributor.author
Castelli, Romina
dc.contributor.author
Ibarra, Manuel
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Faccio, Ricardo
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Miraballes, Iris
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Fernández, Marcelo
dc.contributor.author
Moglioni, Albertina Gladys
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dc.contributor.author
Cabral, Pablo
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Cerecetto, Hugo
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Glisoni, Romina Julieta
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dc.contributor.author
Calzada, Victoria
dc.date.available
2022-09-27T17:49:23Z
dc.date.issued
2021-01
dc.identifier.citation
Castelli, Romina; Ibarra, Manuel; Faccio, Ricardo; Miraballes, Iris; Fernández, Marcelo; et al.; T908 polymeric micelles improved the uptake of Sgc8-c aptamer probe in tumor-bearing mice: A co-association study between the probe and preformed nanostructures; MDPI; Pharmaceuticals; 15; 1; 1-2021; 1-20
dc.identifier.issn
1424-8247
dc.identifier.uri
http://hdl.handle.net/11336/170664
dc.description.abstract
Aptamers are oligonucleotides that have the characteristic of recognizing a target with high affinity and specificity. Based on our previous studies, the aptamer probe Sgc8-c-Alexa647 is a promising tool for molecular imaging of PTK7, which is an interesting biomarker in cancer. In order to improve the delivery of this probe as well as create a novel drug delivery nanosystem targeted to the PTK7 receptor, we evaluate the co-association between the probe and preformed nanostructures. In this work, preformed pegylated liposomes (PPL) and linear and branched pristine polymeric micelles (PMs), based on PEO–PPO–PEO triblock copolymers were used: poloxamer F127® and poloxamines T1307® and T908®. For it, Sgc8-c-Alexa647 and its co-association with the different nanostructures was exhaustively analyzed. DLS analysis showed nanometric sizes, and TEM and AFM showed notable differences between free-and co-associated probe. Likewise, all nanosystems were evaluated on A20 lymphoma cell line overexpressing PTK7, and the confocal microscopy images showed distinctness in cellular uptake. Finally, the biodistribution in BALB/c mice bearing lymphoma-tumor and pharmacokinetic study revealed an encouraging profile for T908-probe. All data obtained from this work suggested that PMs and, more specifically T908 ones, are good candidates to improve the pharmacokinetics and the tumor uptake of aptamer-based probes.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
ACTIVE TARGETING
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LIPOSOMES
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POLYMERIC MICELLES
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PROBE
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SGC8-C APTAMER
dc.subject.classification
Nano-procesamiento
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
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dc.title
T908 polymeric micelles improved the uptake of Sgc8-c aptamer probe in tumor-bearing mice: A co-association study between the probe and preformed nanostructures
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-13T11:05:36Z
dc.journal.volume
15
dc.journal.number
1
dc.journal.pagination
1-20
dc.journal.pais
Suiza
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dc.journal.ciudad
Basel
dc.description.fil
Fil: Castelli, Romina. Universidad de la República; Uruguay
dc.description.fil
Fil: Ibarra, Manuel. Universidad de la República; Uruguay
dc.description.fil
Fil: Faccio, Ricardo. Universidad de la República; Uruguay
dc.description.fil
Fil: Miraballes, Iris. Universidad de la República; Uruguay
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Fil: Fernández, Marcelo. Universidad de la República; Uruguay
dc.description.fil
Fil: Moglioni, Albertina Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
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Fil: Cabral, Pablo. Universidad de la República; Uruguay
dc.description.fil
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
dc.description.fil
Fil: Glisoni, Romina Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Nanobiotecnología. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Nanobiotecnología; Argentina
dc.description.fil
Fil: Calzada, Victoria. Universidad de la República; Uruguay
dc.journal.title
Pharmaceuticals
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1424-8247/15/1/15
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ph15010015
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