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Artículo

Evaluation of the chagas western blot igg assay for the diagnosis of chagas disease

Brossas, Jean Yves; Ballering, Griselda Edith; Bisio, Margarita María CatalinaIcon ; Guihenneuc, Jeremy; Gulin, Julián Ernesto NicolásIcon ; Jauréguiberry, S.; Lescure, François Xavier; Fekkar, Arnaud; Mazier, Dominique; Altcheh, Jaime MarceloIcon ; Paris, Luc
Fecha de publicación: 10/11/2021
Editorial: MDPI
Revista: Pathogens
ISSN: 2076-0817
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Parasitología; Medicina Tropical

Resumen

Chagas disease is a debilitating and often fatal pathology resulting from infection by the protozoan parasite Trypanosoma cruzi. In its recommendations, the World Health Organization states that the diagnosis of T. cruzi infection is usually based on the detection of antibodies against T. cruzi antigens and performed with two methodologically different assays. An inconclusive result can be resolved with a third “confirmatory” assay. The objective of this article is to evaluate the effectiveness of the Chagas Western Blot IgG assay (LDBio Diagnostics, Lyon, France) as a confirmatory serologic test. The Chagas Western Blot IgG assay was performed with native antigens derived from a T. cruzi strain of the TcVI genotype. Retrospective sera were provided by two parasitology laboratories (France and Argentina). The sensitivity, specificity, positive predictive value and negative predictive value of the Chagas blot were all 100% in our sera collection. The Chagas blot is an easy and qualitative method for the diagnosis of Chagas disease, with results in less than 2 h. This immunoblot has potential as a supplemental test for the confirmation of the presence of antibodies against T. cruzi in serum specimens. Nonetheless, the very good initial results presented here will need to be confirmed in larger studies.
Palabras clave: CHAGAS DISEASE , DIAGNOSTIC , TRYPANOSOMA CRUZI
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/170558
DOI: https:// doi.org/10.3390/pathogens10111455
URL: https://www.mdpi.com/1422-0067/22/5/2414
Colecciones
Articulos(IMIPP)
Articulos de INSTITUTO MULTIDISCIPLINARIO DE INVESTIGACIONES EN PATOLOGIAS PEDIATRICAS
Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Citación
Brossas, Jean Yves; Ballering, Griselda Edith; Bisio, Margarita María Catalina; Guihenneuc, Jeremy; Gulin, Julián Ernesto Nicolás; et al.; Evaluation of the chagas western blot igg assay for the diagnosis of chagas disease; MDPI; Pathogens; 10; 11; 10-11-2021; 1-10
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