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dc.contributor.author
Maritano Furcada, Joaquín
dc.contributor.author
Castro, Horacio Matías
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de Vito, Eduardo
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Grande Ratti, María Florencia
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Posadas Martinez, Maria Lourdes
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Giunta, Diego Hernan
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Vazquez, Fernando Javier
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Ferreyro, Bruno Leonel
dc.date.available
2022-09-26T19:24:30Z
dc.date.issued
2020-12
dc.identifier.citation
Maritano Furcada, Joaquín; Castro, Horacio Matías; de Vito, Eduardo; Grande Ratti, María Florencia; Posadas Martinez, Maria Lourdes; et al.; Diagnosis of pulmonary embolism in patients with acute exacerbations of chronic obstructive pulmonary disease: a cross-sectional study; Wiley Blackwell Publishing, Inc; Clinical Respiratory Journal; 14; 12; 12-2020; 1-17
dc.identifier.issn
1752-6981
dc.identifier.uri
http://hdl.handle.net/11336/170498
dc.description.abstract
Introduction: Pulmonary embolism (PE) remains a frequent complication in patients with chronic obstructive pulmonary disease (COPD). It is unclear that the extent to which the traditional risk stratifying scores for PE are accurate in this population. Methods: Cross-sectional study of adult patients with COPD and suspected PE included in an Institutional Registry of Thromboembolic Disease at a tertiary teaching hospital in the city of Buenos Aires, Argentina. We estimated the area under the receiver operating characteristic curves (AU-ROC), sensitivity and specificity of the Wells and Geneva scores using a positive computed tomography angiography as the gold standard for PE. We also estimated the sensitivity and specificity for the presence of isolated worsening of dyspnea at presentation, without other cardinal symptoms of acute exacerbation of COPD. Results: A total of 168 patients were included, of which 22% had confirmed PE. The AUC was 0.66 (95% CI 0.56-0.76) and 0.56 (95% CI 0.45-0.67) for the Wells and Geneva, respectively. Considering the most widely used cutoff points, the sensitivity and specificity were 24% and 90% for the Wells and 59% and 43% for the Geneva score, respectively. Isolated worsening of dyspnea on presentation had a sensitivity of 92% and specificity of 37%. Conclusions: Both Wells and Geneva scores exhibit poor diagnostic accuracy for the diagnosis of PE in patients with COPD. The presence of isolated worsening of dyspnea on presentation could be an easy to identify criteria for the initial triage in this population. Further validation of our findings remains warranted.
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application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
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PULMONARY EMBOLISM
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Sistemas Cardíaco y Cardiovascular
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Diagnosis of pulmonary embolism in patients with acute exacerbations of chronic obstructive pulmonary disease: a cross-sectional study
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-23T15:41:53Z
dc.journal.volume
14
dc.journal.number
12
dc.journal.pagination
1-17
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Maritano Furcada, Joaquín. Hospital Italiano; Argentina
dc.description.fil
Fil: Castro, Horacio Matías. Hospital Italiano; Argentina
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Fil: de Vito, Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
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Fil: Grande Ratti, María Florencia. Hospital Italiano; Argentina
dc.description.fil
Fil: Posadas Martinez, Maria Lourdes. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Hospital Italiano; Argentina
dc.description.fil
Fil: Giunta, Diego Hernan. Hospital Italiano; Argentina
dc.description.fil
Fil: Vazquez, Fernando Javier. Hospital Italiano; Argentina
dc.description.fil
Fil: Ferreyro, Bruno Leonel. Hospital Italiano; Argentina. University of Toronto; Canadá
dc.journal.title
Clinical Respiratory Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/crj.13257
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/crj.13257
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