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Artículo

Phylogenomics, CAZyome and core secondary metabolome of Streptomyces albus species

Vela Gurovic, Maria SoledadIcon ; Díaz, Marina Lucía; Gallo, Cristian AndrésIcon ; Dietrich, Julián
Fecha de publicación: 26/09/2021
Editorial: Springer Heidelberg
Revista: Molecular Genetics And Genomics
ISSN: 1617-4615
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biología Celular, Microbiología

Resumen

A phylogenomic study conducted with different bioinformatic tools such as TYGS, REALPHY and AAI comparisons revealed a high AQ1 rate of misidentified Streptomyces albus genomes in GenBank. Only 9 of the 18 annotated genomes available in the public database were correctly identified as S. albus species. The pangenome of the nine in silico confirmed S. albus genomes was almost closed. Lignocellulosic agroresidues were a common niche among strains of the S. albus clade while carbohydrate active enzymes (CAZymes) were highly conserved. Relevant enzymes for cellulose degradation such as beta glucosidases belonging to the GH1 family, a GH6 cellulase and a monooxygenase AA10-CBM2 were encoded by all S. albus genomes. Among them, one GH1glycosidase would be regulated by CebR. However, this regulatory mechanism was not confirmed for other genes related to cellulose degradation. Based on AntiSMASH predictions, the core secondary metabolome of S. albus encompassed a total of 23 biosynthetic gene clusters (BGCs), where 4 were related to common metabolites within Streptomyces genus. Species specific BGCs included those related to pseudouridimycin and xantholipin. Additionally, four BGCs encoded putative derivatives of ibomycin, the lasso peptide SSV2086, the lanthipeptide SapB and the terpene isorenieratene. Known metabolites could not be assigned to ten BGCs and three clusters did not match with any previously described BGC. The core genome of S. albus retrieved from nine closely related genomes revealed a high potential for the discovery of novel bioactive metabolites and underexplored regulatory genomic elements related to lignocellulose deconstruction.
Palabras clave: CAZYME , CELLULOSE , COMPARATIVE GENOMICS , PLANT BIOMASS , SECONDARY METABOLOME , STREPTOMYCES ALBUS
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/170456
URL: https://link.springer.com/10.1007/s00438-021-01823-9
DOI: http://dx.doi.org/10.1007/s00438-021-01823-9
Colecciones
Articulos(CERZOS)
Articulos de CENTRO REC.NAT.RENOVABLES DE ZONA SEMIARIDA(I)
Citación
Vela Gurovic, Maria Soledad; Díaz, Marina Lucía; Gallo, Cristian Andrés; Dietrich, Julián; Phylogenomics, CAZyome and core secondary metabolome of Streptomyces albus species; Springer Heidelberg; Molecular Genetics And Genomics; 296; 6; 26-9-2021; 1299-1311
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