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dc.contributor.author
del Priore, Lucía
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dc.contributor.author
Pigozzi, Maria Ines
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dc.date.available
2022-09-23T16:29:10Z
dc.date.issued
2021-02-27
dc.identifier.citation
del Priore, Lucía; Pigozzi, Maria Ines; Dna organization along pachytene chromosome axes and its relationship with crossover frequencies; MDPI AG; International Journal of Molecular Sciences; 22; 5; 27-2-2021; 1-12
dc.identifier.issn
1422-0067
dc.identifier.uri
http://hdl.handle.net/11336/170261
dc.description.abstract
During meiosis, the number of crossovers vary in correlation to the length of prophase chromosome axes at the synaptonemal complex stage. It has been proposed that the regular spacing of the DNA loops, along with the close relationship of the recombination complexes and the meiotic axes are at the basis of this covariation. Here, we use a cytogenomic approach to investigate the relationship between the synaptonemal complex length and the DNA content in chicken oocytes during the pachytene stage of the first meiotic prophase. The synaptonemal complex to DNA ratios of specific chromosomes and chromosome segments were compared against the recombination rates obtained by MLH1 focus mapping. The present results show variations in the DNA packing ratios of macro-and microbivalents and also between regions within the same bivalent. Chromosome or chromosome regions with higher crossover rates form comparatively longer synaptonemal complexes than expected based on their DNA content. These observations are compatible with the formation of higher number of shorter DNA loops along meiotic axes in regions with higher recombination levels.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI AG
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
BIRD CHROMOSOMES
dc.subject
CROSSING OVER
dc.subject
FLUORESCENT IN SITU HYBRIDIZATION
dc.subject
IMMUNOSTAINING
dc.subject
MEIOSIS
dc.subject
MLH1 FOCUS MAP
dc.subject
MOLECULAR CYTOGENETICS
dc.subject
RECOMBINATION FREQUENCIES
dc.subject
SYNAPTONEMAL COMPLEX
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Dna organization along pachytene chromosome axes and its relationship with crossover frequencies
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2022-09-21T14:28:38Z
dc.journal.volume
22
dc.journal.number
5
dc.journal.pagination
1-12
dc.journal.pais
Suiza
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dc.description.fil
Fil: del Priore, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Pigozzi, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.journal.title
International Journal of Molecular Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/5/2414
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms22052414
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